Springbok coach Rudolf Straeuli has shuffled his side set to face Wales at Newlands on Saturday.
He has named a squad of 22 that will play in the second test after the Dragons gave them a real fright in the opening match.
In come centre De Wet Barry, openside flank Corne Krige, utility back Werner Greeff and lock Hottie Louw, while Victor Matfield, Andre Snyman, Warren Britz and, through injury, Ricardo Loubscher have been left out.
Both Krige and Barry had originally been pencilled into the squad for the first test but were struck down with a rib and ankle injury respectively.
Having recovered they have replaced Britz and Snyman who underperformed for the Boks in the 34-19 win in Bloemfontein.
Straeuli said: "It is encouraging that the likes of Krige and Barry have recovered from injury. They add depth to our 22. Naturally, there will be disappointed players, but the onus on those who have not made it is to fight their way back.
"The positive from Bloemfontein was that we won, but we as a team are constantly looking for improvement."
Meanwhile, Steve Hansen is poised to name his team for the crunch second test on Thursday with Wales' 1,000th international player Michael Owen expected to keep his place in the wake of a sensational debut.
Backs: De Wet Barry, Johannes Conradie, Craig Davidson, Werner Greeff, Adrian Jacobs, Marius Joubert, Breyton Paulse, André Pretorius, Brent Russell and Stefan Terblanché.
Forwards: James Dalton, Quinton Davids, Daan Human, Corné Krige, Jannes Labuschagne, Ollie le Roux, Hottie Louw, Willie Meyer, Faan Rautenbach, Bob Skinstad, Joe van Niekerk, AJ Venter.
The WRU has launched a campaign to create a long term legacy for Welsh club rugby by highlighting the advantages of volunteering. Rhian Edwards, a volunteer at Seven Sisters, has enjoyed many benefits of her volunteering at a grassroots rugby club including being part of the Rugby World Cup volunteer workforce after being nominated by the WRU - and the WRU is asking for more people to develop their 'Welsh rugby roots'.
Wales head coach Warren Gatland and captain Sam Warburton say their first prioirty on Sunday in the opening game of the World Cup is to win against Uruguay and not get overly concerned with points difference.
With only days to go until the biggest rugby competition in the world begins, rugby fans visiting Cardiff this autumn will be able to enjoy a special display at National Museum Cardiff as part of the celebrations surrounding the Rugby World Cup.
Geraint John has taken up the new role of WRU elite coach development manager having arrived in Wales last week. WRU TV caught up with him at the WRU rugby department's strategy day at the Millennium Stadium.