Springbok coach Rudolf Straeuli has warned Wales that his side will be pumped up for the second Test at Newlands.
He has named a side showing four changes to the team that beat Wales 34-19 at Bloemfontein on Saturday.
Stormers hard man Quinton Davids and Corne Krige have been brought in to add extra muscle to South Africa's pack.
There are also two changes behind the scrum with inside centre De Wet Barry taking over from dropped Andre Snyman.
Meanwhile, Brent Russell moves to full back with Andre Pretorius reclaiming the fly-half spot.
"I don't have to say much about Krige coming back. Loubscher was injured and we are happy with Brent playing at full-back.
"De Wet Barry is an out-and-out inside centre and it's nice to have someone like Quinton starting on his home patch."
South Africa team: Brent Russell; Stefan Terblanche, Marius Joubert, De Wet Barry, Breyton Paulse; Andre Pretorius, Johannes Conradie; Daan Human, James Dalton, Willie Meyer, Quinton Davids, Jannes Labuschagne, Corne Krige, Bobbie Skinstad (capt), Andre Venter
Replacements: Ollie le Roux, Faan Rautenbach, Hottie Louw, Joe Van Niekerk, Craig Davidson, Adrian Jacobs, Werner Greeff
The Wales Women's team headed to Dare Valley Country Park on a team bonding exercise as the entire squad got together for the very first time in preparation for this season's Six Nations championship which kicks off on Saturday with a clash against defending champions Ireland, in Donnybrook.
Wales Head Coach Warren Gatland discusses his team selection for the opening round of the RBS 6 Nations where he leads his side against Ireland, on Sunday. As WRU TV's Luke Brodley discovers, Gatland is fully aware of the challenges the defending champions pose
WRUTV caught up with Wales Women captain Rachel Taylor at the RBS 6 Nations launch and how a good crowd really helps boost the girls performance. Tickets for all three Women's home games at The Gnoll, Neath are available from www.wru.wales/tickets