Springbok coach Rudolf Straeuli has warned Wales that his side will be pumped up for the second Test at Newlands.
He has named a side showing four changes to the team that beat Wales 34-19 at Bloemfontein on Saturday.
Stormers hard man Quinton Davids and Corne Krige have been brought in to add extra muscle to South Africa's pack.
There are also two changes behind the scrum with inside centre De Wet Barry taking over from dropped Andre Snyman.
Meanwhile, Brent Russell moves to full back with Andre Pretorius reclaiming the fly-half spot.
"I don't have to say much about Krige coming back. Loubscher was injured and we are happy with Brent playing at full-back.
"De Wet Barry is an out-and-out inside centre and it's nice to have someone like Quinton starting on his home patch."
South Africa team: Brent Russell; Stefan Terblanche, Marius Joubert, De Wet Barry, Breyton Paulse; Andre Pretorius, Johannes Conradie; Daan Human, James Dalton, Willie Meyer, Quinton Davids, Jannes Labuschagne, Corne Krige, Bobbie Skinstad (capt), Andre Venter
Replacements: Ollie le Roux, Faan Rautenbach, Hottie Louw, Joe Van Niekerk, Craig Davidson, Adrian Jacobs, Werner Greeff
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.