Swansea half-back Gavin Henson, Bath scrum-half Andy Williams and Newport pair Andy Powell and Hal Luscombe have all ruled themselves out of the Under 21 World Cup which commences for Wales against Italy in Johannesburg's Ellis Park next Thursday.
The prodigious Henson was expected to be named as part of coach Chris Davey's 26-strong squad but the 20 year-old has surprisingly ruled himself out - handing the Wales number 10 jersey to rival Nicky Robinson.
Davey confirmed, "Gavin has made himself unavailable for the World Cup, we are not really sure why.
"He has not had the best of seasons although he started the Six Nations Championship in good form for us, I only hope that the added competition for places at Swansea next season will bring out the best in him."
The Welsh World Cup campaign has also been denied the services of up-and-coming Newport no 8 Andy Powell who feels he needs to rest after a demanding season.
Bath scrum-half Andy Williams and Newport centre Hal Luscombre have also declined the offer of a place.
However Davey is confident the side can live up to expectations.
"Having been seeded fourth we have to target a top four finish," he added.
"The boys have tried and tested themselves at Six Nations level and proved they can compete very well. This will be another step up from that and will be a very good experience. The opening game against Italy should be a good one to get us going."
After the Italian game, Wales take on Argentina on Tuesday June 18 with their final game against favourites New Zealand on Friday June 21.
The team will be skippered by Swansea's Matthew Bayley.
Wales Under 21 World Cup squad:
G Swayles (Swansea), M Nuttall (Pontypridd), K Morris (Caerphilly), L Roberts (Cardiff), N Jones (UWIC), M Jones (Neath), M Bayley (capt, Swansea), S Williams (Newport), N Robinson (Cardiff), M Hook (Newport), M Phillips (Llanelli), C Miller (Cardiff); P James, A Jones, P Matthews (all Neath), C Jones (Llanelli), M Miles (Northampton), G Morris (Pontypridd), B Griffiths (Llanelli), L Tait (Cardiff), L Charteris (Newport), R Jones (Bridgend), R Williams (Ebbw Vale), G Williams (Llanelli), R Sowden-Taylor (Cardiff), R Jones (Newport)
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series