The match, which will be played biennially, and from which the proceeds will be used to assist a selected number of financially disadvantaged countries, will follow the Autumn Internationals. It is anticipated that all the world's leading players will take part.
John O'Neill, Managing Director/CEO of the Australian Rugby Union said, "This initiative will help to re-establish and rejuvenate the game amongst proud rugby communities like Fiji, Samoa, Tonga and Romania, and help to create a much more competitive structure at the elite level".
Rian Oberholzer, Managing Director of South African Rugby added, "This represents a unique opportunity for the rugby community to unite and assist those countries experiencing financial difficulty."
Dr Syd Millar, former Irish and British Lions prop forward, and Chairman of the IRB Technical Committee will be responsible for appointing the coaches of the two teams and Michael Lynagh, newly appointed to the IRB in a development role, will act as Match Manager.
Following the match in Cardiff, the IRB will hold the Annual International Awards Ceremony at which the outstanding achievements of the rugby year, both on and off the field, will be recognised.
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series