Out go Naomi Thomas with a stress fracture of the shin and Hayley Baxter with a fractured scaphoid. Both UWIC players had been earmarked to play against Australia in the opening fixture and their attacking prowess will be sorely missed.
Their replacements are Cath Foale from Saracens and Gemma Allen from Tylorstown Tigers.
The annual Women's club launch was held at the Wales Centre of Excellence where National Women's Head Coach and Programme Lead Rhys Edwards, Competition Secretary Adrian Howell and Cardiff Met player Ffion Jones express eagerness for the new campaign to get under way.
WRU TV follows Wales' RWC training squad on day one of their camp in North Wales. The squad were greeted to an official welcome in Colwyn Bay and then headed for an afternoon of team building at ZipWorld