The Arms Park youngsters will start the game as favourites after defeating the Welsh All Blacks in two league clashes and Cardiff secured the league title last weekend after their 26pts to 20 win over Bridgend.
Neath are battling for the runners up position but will be looking to deny the Arms Park side an unique league and cup double in the competitions inaugural final.
Ryan Williams starts at scrum half partnering Dylan Pugh, who contributed so effectively to the semi-final success away to Pontypridd. Wing Andrew Jones returns while the pack remains unchanged.
Cardiff show just two changes from the side which defeated Llanelli in the last round with Darren Ryan selected at centre and lock Tait returning to the side after his recent run in the senior side.
Neath U'21s: P.Thomas, R.Carter, M.Jones, P.Smiriglia, A.Jones, D.Pugh, R.Williams, P.James, A.Matthews (capt), A.Jones, G.Evans, L.Bassett, S.Peters, D.Evans, S.Phillips
Cardiff U'21s: C.Anderson, E.Jones, O.Ashman, D.Ryan, G.Williams, N.Macleod, C.Miller (capt), J.Yapp, K.Jarma, D.Evans, L.Tait, C.Stamatakis, J.Malpas, M.Leach, M.Leaman
The annual Women's club launch was held at the Wales Centre of Excellence where National Women's Head Coach and Programme Lead Rhys Edwards, Competition Secretary Adrian Howell and Cardiff Met player Ffion Jones express eagerness for the new campaign to get under way.
WRU TV follows Wales' RWC training squad on day one of their camp in North Wales. The squad were greeted to an official welcome in Colwyn Bay and then headed for an afternoon of team building at ZipWorld