Fly half Nicky Robinson and lock Damian Hudd, who were replacements during the match against France, replace Gavin Henson and Bryn Griffiths respectively.
Wales meet Italy for the fourth time, having won the previous matches - 78-19 at Udine in 1999; 95-0 at Newport in 2000 and 16-3 at Parma last year. Skipper Matthew Brayley and flanker Rhys Williams are the only survivors from last season's victory.
Team: 15 Gareth Swales (Swansea); 14 Liam Roberts (Cardiff), 13 Hal Luscombe (Newport), 12 Matthew Brayley (Swansea, capt), 11 Nicky Jones (UWIC); 10 Nicky Robinson (Cardiff), 9 Michael Phillips (Llanelli); 1 Paul James (Neath), 2 Adam Matthews (Neath), 3 Adam Jones (Neath), 4 Luke Tait (Cardiff), 5 Damian Hudd (Ebbw Vale), 6 Rhys Williams (Ebbw Vale), 7 Gareth Williams (Llanelli), 8 Rhys Jones (UWIC).
Replacements: 16 Matthew Miles (Northampton), 17 Phil John (Llanelli), 18 Ceiron Jones (Llanelli), 19 Bryn Griffiths (Llanelli), 20 Aled Gravelle (Llanelli), 21 Chris Miller (Cardiff), 22 Gavin Henson (Swansea)
The annual Women's club launch was held at the Wales Centre of Excellence where National Women's Head Coach and Programme Lead Rhys Edwards, Competition Secretary Adrian Howell and Cardiff Met player Ffion Jones express eagerness for the new campaign to get under way.
WRU TV follows Wales' RWC training squad on day one of their camp in North Wales. The squad were greeted to an official welcome in Colwyn Bay and then headed for an afternoon of team building at ZipWorld