The son of four-times capped former Wales international threequarter Jim Shanklin, Tom scored two tries on his international debut, in the 53-30 second Test victory over Japan in Tokyo last summer. His Championship debut comes 32 years after his father made his bow, also against the French.
He features among three changes new National Coach Steve Hansen has made from the starting line-up against Ireland 10 days ago for his first international in charge.
Shanklin and Newport's Andy Marinos - the latter came on as a 10th minute replacement in Dublin - form a new centre partnership with Jamie Robinson ruled out with an ankle injury and Iestyn Harris named among the replacements.
Andy Moore (Swansea) replaces ankle injury victim Chris Wyatt in the second row, Llanelli lock Wyatt failing an 11th hour fitness test.
"We selected the strongest available team against Ireland and we are currently trying to get some consistency into selection and feel that, by doing so, we will get the improvement we are looking for," said Hansen.
"Tom Shanklin's selection is down to the fact he was the in-form centre in the Wales A side and, with the odd exception, it is from that source our future selections will come."
Gavin Thomas (Bath Rugby) comes in for Neath's Brett Sinkinson on the replacement bench as part of the selection policy.
"The change between Brett and Gavin on the bench is because Brett has been selected to play for the A team on Friday night as part of the consistent rota policy where players sustain match fitness by playing in the A team rather than sit on the bench," said Hansen.
"Both players have been aware of our intentions regarding the rota policy."
LLOYDS TSB SIX NATIONS CHAMPIONSHIP 2002
Wales v France
Saturday, 16th February
Kick-off: 2.00 pm
15 Kevin Morgan (Swansea)
14 Dafydd James (Bridgend)
13 Tom Shanklin (Saracens)
12 Andy Marinos (Newport Rugby)
11 Craig Morgan (Cardiff)
10 Stephen Jones (Llanelli)
9 Robert Howley (Cardiff)
1 Spencer John (Cardiff)
2 Robin McBryde (Llanelli)
3 Chris Anthony (Newport Rugby)
4 Craig Quinnell (Cardiff)
5 Andy Moore (Swansea)
6 Nathan Budgett (Bridgend)
7 Martyn Williams (Cardiff)
8 Scott Quinnell (Llanelli, captain)
16 Barry Williams (Neath)
17 Duncan Jones (Neath)
18 Ian Gough (Newport Rugby)
19 Gavin Thomas (Bath Rugby)
20 Dwayne Peel (Llanelli)
21 Iestyn Harris (Cardiff)
22 Rhys Williams (Cardiff)
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.