Ian Gough, the Newport Rugby second row forward, will start his first international of this season's Lloyds TSB Six Nations Championship when he packs down with Swansea's Andy Moore against Italy at the Millennium Stadium on Saturday (kick-off 2.00 pm).
Gough, who came on as a replacement against both Ireland and France, takes over from the injured Craig Quinnell with fit again Chris Wyatt (Llanelli) on the replacements bench.
In the only other change from the starting line-up against France, Ebbw Vale prop Iestyn Thomas takes over from Spencer John on the loosehead as Wales go in search of their first win of the 2002 tournament.
Thomas broke a toe early in the match against Tonga on 17 November, 2001, but has forced his way back into the front row after impressing for Wales A in the 17-6 victory over France A 12 days ago.
"It was a frustrating time for me when I suffered the injury but since then I have had a good run of games," said Thomas, who will win his 10th cap on Saturday. "I am just glad I have done enough to be back in the national team."
Gough, who will be playing in his 19th Test, said: "It is great to be back in the starting line-up, it gives you the chance to make your mark on the match and I just hope to be part of a successful Wales team."
Coach Steve Hansen, in charge for his second international, has given a blanket vote of confidence to the back division.
Scrum half Rob Howley will win his 57th cap on Saturday - putting him up into the "Big Five" on the Welsh international appearance chart, one ahead of Gareth Thomas and behind only Neil Jenkins (84), Ieuan Evans (72), Gareth Llewellyn (64) and Garin Jenkins (58).
LLOYDS TSB SIX NATIONS CHAMPIONSHIP 2002
WALES v ITALY, Millennium Stadium Saturday, 2nd March Kick-off: 2.00 pm
15 Kevin Morgan (Swansea)
14 Dafydd James (Bridgend)
13 Tom Shanklin (Saracens)
12 Andy Marinos (Newport Rugby)
11 Craig Morgan (Cardiff)
10 Stephen Jones (Llanelli)
9 Robert Howley (Cardiff)
1 Iestyn Thomas (Ebbw Vale)
2 Robin McBryde (Llanelli)
3 Chris Anthony (Newport Rugby)
4 Ian Gough (Newport Rugby)
5 Andy Moore (Swansea)
6 Nathan Budgett (Bridgend)
7 Martyn Williams (Cardiff)
8 Scott Quinnell (Llanelli, captain)
16 Barry Williams (Neath)
17 Spencer John (Cardiff)
18 Chris Wyatt (Llanelli)
19 Brett Sinkinson (Neath)
20 Dwayne Peel (Llanelli)
21 Iestyn Harris (Cardiff)
22 Rhys Williams (Cardiff)
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series