Irish coach Eddie O'Sullivan's injury plagued build-up to his first game in charge of the national side has seen him have to rule out four senior players for the Lloyds TSB Six Nations opener against Wales at Lansdowne Road on Sunday, 3 February.
Following on from the early withdrawals of skipper Keith Wood and fellow British Lion Malcolm O'Kelly, the Ierish coach has also seen Leinster duo Shane Horgan and Eric Miller drop out. In addition, Leinster prop Emmet Byrne could also not be considered through injury.
It has meant a major reshuffle of his side and a heavy reliance on the Munster side that reached the semi-finals of the Heineken Cup for the third successive season last weekend with a magnificent victory in Paris over Stade Francais.
O'Sullivan has handed a first cap to young Munster lock Paul O'Connell, who was man of the match in Paris, in the absenece of O'Kelly, while Munster hooker Frank Sheahan comes in for Wood at hooker to make his first start in the Six Nations Championship.
That means Munster provide the whole of the front five, seven members of the pack and eight players overall to the side.
Peter Stringer appears at scrum half and to make it an even greater day for the Munster contingent, their captain Mick Galwey will lead the side in the absence of Wood and prop Peter Clohessy will win his 50th cap.
Up front, Llanelli's Simon Easterby is the odd man out, while Leicester Tigers full back Geordan Murphy comes in on the right wing. He fills in for Bath's kevin maggs, who switches to centre in the absence of Horgan.
Leinster's uncapped flanker Keith Gleeson, Dublin-born but a former captain of Australia Under 21, comes in on the replacements bench due to the absence of team mate Miller.
O'Sullivan has still to decide on a prop replacement and has named an AN Other on the bench.
Girvan Dempsey (Leinster); Geordan Murphy (Leicester Tigers), Brian O'Driscoll (Leinster), Kevin Maggs (Bath), Denis Hickie (Leinster; David Humphreys (Ulster), Peter Stringer (Munster); Peter Clohessy (Munster), Frank Sheahan (Munster), John Hayes (Munster); Mick Galwey (Munster, CAPTAIN), Paul O'Connell (Munster), Simon Easterby (Llanelli), David Wallace (Munster), Anthony Foley (Munster)
Shane Byrne (Leinster), AN Other, Gary Longwell (Ulster), Keith Gleeson (Leinster), Guy Easterby (Llanelli), Ronan O'Gara (Munster), Rob Henderson (Munster).
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.