Centre Matthew Brayley of Swansea and flanker Rhys Williams of Ebbw Vale are the duo, but at half back is an exciting pairing of Gavin Henson (Swansea) and Andrew Williams (Bath).
With no meeting against Ireland last season due to the foot and mouth epidemic, Wales lead by five wins to four in their previous nine meetings, while in all under-21 matches in the Northern Hemisphere, Wales have won 34 and lost only 10 times.
Backs Gareth Swales, the South African-born Hal Luscombe and Brayley along with lock Griffiths all played in the under-21 A side that drew with England A at Pontypridd in December.
Several of the side have already played in National League rugby, but the most interesting selections are the complete Neath under-21 trio in the front row with the highly-rated hooker Adam Matthews having Paul James and Adam Jones as his props.
Wales under-21: Gareth Swales (Swansea); Liam Roberts (Cardiff), Matthew Brayley (Swansea), Hal Luscombe (Newport), Nicky Jones (UWIC); Gavin Henson (Swansea), Andrew Williams (Bath); Paul James (Neath), Adam Matthews (Neath), Adam Jones (Neath), Alex Davidson (Gloucester & Hartbury Coll)
Bryn Griffiths (Llanelli), Rhys Williams (Ebbw Vale), Gareth Williams (Llanelli), Rhys Jones (UWIC). Replacements: Matthew Miles
(Northampton), Ceiron Jones (Llanelli), Phil John (Llanelli), Damian Hudd (Ebbw Vale)Aled Gravell (Llanelli), Michael Phillips (Llanelli), Nicky Robinson (Cardiff).
1991. Wales won 22-15 (at Newport).
1992. Ireland won 22-11 (at Donnybrook).
1993. No match.
1994. Wales won 27-5 (at Carlow).
1995. Wales won 16-9 (at Glamorgan Wanderers).
1996. Ireland won 20-12 (at Wicklow).
1997. Wales won 44-16 (at Bridgend.
1998. Ireland won 27-25 (at Donnybrook).
1999. Wales won 24-18 (at Caerphilly).
2000. Ireland won 35-17 (at Limerick).
2001. No match.
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series