Principality Cup holders Newport will launch their defence of the title at First Division Bonymaen.
Bonymaen are one of six First Diviasion clubs to reach the last 16 and their reward, along with Aberavon, Blackwood, Carmarthen Quins, Newbridge, Pontypool, as welklk as Second Divison leaders Narberth, are home ties in the seventh round.
That means a potentially lucrative clash with a Welsh/Scottish League club, who this season agreed to be drawn away from home at this stage.
Ebbw Vale's victory at Llandovery in round six earned them a home draw and they will face fellow Premiership side Neath.
First Division leaders Aberavon will host Cardiff in a game that sees the two sides clash for a sixth time in the cup. Cardiff currently lead 3-2.
Newbridge will meet Llanelli, a team they once faced in the semi-finals, while Pontypool's showdown with Swansea is a repeat of their 1983 Cup final meeting when the Gwwent side won the title for the first time.
Glyncoch have had a remarkable past couple of seasons, having lost just once in the last two seasons. Their fine form has been capped by claiming the South Central Division 5 crown of the SWALEC League.
With two rounds of the HSBC Sevens World Series remaining, Wales head coach Paul John has sprung a few surprises for this week's penultimate round in Glasgow. And there's still plenty to play for with World Cup spots on the line.