Principality Cup holders Newport will launch their defence of the title at First Division Bonymaen.
Bonymaen are one of six First Diviasion clubs to reach the last 16 and their reward, along with Aberavon, Blackwood, Carmarthen Quins, Newbridge, Pontypool, as welklk as Second Divison leaders Narberth, are home ties in the seventh round.
That means a potentially lucrative clash with a Welsh/Scottish League club, who this season agreed to be drawn away from home at this stage.
Ebbw Vale's victory at Llandovery in round six earned them a home draw and they will face fellow Premiership side Neath.
First Division leaders Aberavon will host Cardiff in a game that sees the two sides clash for a sixth time in the cup. Cardiff currently lead 3-2.
Newbridge will meet Llanelli, a team they once faced in the semi-finals, while Pontypool's showdown with Swansea is a repeat of their 1983 Cup final meeting when the Gwwent side won the title for the first time.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.