Llanelli look to be the best-placed club to surge into the quarter finals and a win against French giants Perpignan would provide a huge boost to the side currently top of the Welsh-Scottish league.
A win in France would blow the group wide open and set up a winner-takes-all showdown against Leicester next week at Stradey Park.
Judging from past seasons, the West Wales side have every reason to remain optimistic as they prepare to take on the French side.
Victories over Bourgoin and Colomiers prove the Scarlets have discovered the secret ingredient of winning on French soil.
Scott Quinnell will start the game from the bench having been ruled out for the last month with a knee injury, but is expected to play a part in the game.
Coach Gareth Jenkins said: "This is a big game for us and we know we have to win if we are to progress in the tournament.
"The secret to playing on French soil is not to try and play a running game because there is noone better than the French at that. What you have to do is try and silence the crowd which in turn will affect the team's temperament."
Meanwhile, Cardiff will be bidding to keep their Heineken Cup dreams alive with a morale boosting win over Montferrand at the Arms Park.
The Blue and Blacks have to win their two remaining games if they are to remain in contention for one of the best runner up spots.
The Welsh side will have received a boost with the news that Montferrand openside flanker Olivier Magne has been ruled out through injury.
Bridgend could do Cardiff a huge favour if they beat Castres at the Brewery Field on Saturday. A victory over the French club would increase Cardiff's chances of claiming one of the elusive runners-up positions.
Despite having lost all four games so far, the Ravens will be looking to end the group stages on a high note.
Newport will be hoping to keep alive their slim chances of clinching qualification when they lock horns with another French giant Toulouse.
Qualification for the last eight may be out of their hands following an agonising home defeat against Leinster, but Newport could still go through if they beat Toulouse and then Newcastle next week and other results are kind to them.
Swansea, who face Bath at St Helen's tomorrow, have delayed naming their side because of injury problems.
Wales lock Andy Moore has been ruled out with a neck strain while flanker Colin Charvis is doubtful.
The Whites have a mathematical chance of still qualifying but would have to run in five more tries than Bath following their 38-9 reverse at the Recreation Ground last October.
Wales Under 18 captain Callum Bradbury is delighted to have seen his side claim a narrow 18-17 victory against a strong SA Schools 'A' side to end the three-match Under 19 International Series in South Africa on a high note.
The Wales U18 squad spent an emotional day in the drug-riddled townnship of Hout Bay. Hout Bay Warriors President Fred Johannes said the visit was 'the talk of the town' and will dream about the day everyday for the rest of his life.
RGC 1404's new head coach Mark Jones is hoping to build 'something special' in north Wales and is already looking forward to the development region participating in the Principality Premiership for the very first time.
A joint venture between the WRU and Admiral saw hundreds of children enjoy the Admiral Festival of Rugby held at the National Centre of Excellence at the weekend where Welsh internationals Sam Warburton, Scott Williams and Rob Evans were in attendance.
Wll Jones leads Wales U18s into battle this afternoon against Italy where the Welsh side will be seeking to bounce back from their narrow defeat to SA Schools in their opening clash of the U19 International Series
All four regions attended a successful training camp staged last weekend at the WRU National Centre of Excellence. It was a chance for new Wales Women's head coach Rowland Phillips to deliver his key messages to players and coaches as he prepares for the new season.
Wales U18 Team Manager Gethin Watts believes the next couple of weeks will be 'extremely beneficial' to the future of Welsh rugby as his side prepare to take part in the Under 19 International Series being staged in South Africa.
The WRU is searching for 12 new rugby development apprentices following a successful first year of its WRU Coach Core programme. Craig Duncan and Jess Hancock have flourished in the first year of the programme which has given them a real direction in their lives.
The WRU signed TV comedian Rhod Gilbert up to a 'Coaching Children Level 1' course before letting him loose on an U8s side at Whitland Junior Borderers - we went behind the scenes to film the making of 'Rhod Gilbert's Work Experience' see the results here.
Llandovery are aiming to make it three titles in a row in this year's Foster's National 7s being held at BT Sport Cardiff Arms Park on Sunday 28 August. Drovers assistant coach Simon Davies and Lee Rees assess their sides chances
A pioneering strength and conditioning programme has been delivered to more than 8000 boys and girls at hub schools throughout Wales this season, helping to develop stronger, more flexible athletes for rugby and other sports.
The Singha Premiership Rugby 7s Series returns to the BT Sport Cardiff Arms Park on July 22nd when all four Welsh regions go head to head. Scarlets skills coach Dai Flanagan and Blues Elite Performance Pathway Manager Richard Hodges along with current Welsh squad members were at the launch of this season's event