Llanelli look to be the best-placed club to surge into the quarter finals and a win against French giants Perpignan would provide a huge boost to the side currently top of the Welsh-Scottish league.
A win in France would blow the group wide open and set up a winner-takes-all showdown against Leicester next week at Stradey Park.
Judging from past seasons, the West Wales side have every reason to remain optimistic as they prepare to take on the French side.
Victories over Bourgoin and Colomiers prove the Scarlets have discovered the secret ingredient of winning on French soil.
Scott Quinnell will start the game from the bench having been ruled out for the last month with a knee injury, but is expected to play a part in the game.
Coach Gareth Jenkins said: "This is a big game for us and we know we have to win if we are to progress in the tournament.
"The secret to playing on French soil is not to try and play a running game because there is noone better than the French at that. What you have to do is try and silence the crowd which in turn will affect the team's temperament."
Meanwhile, Cardiff will be bidding to keep their Heineken Cup dreams alive with a morale boosting win over Montferrand at the Arms Park.
The Blue and Blacks have to win their two remaining games if they are to remain in contention for one of the best runner up spots.
The Welsh side will have received a boost with the news that Montferrand openside flanker Olivier Magne has been ruled out through injury.
Bridgend could do Cardiff a huge favour if they beat Castres at the Brewery Field on Saturday. A victory over the French club would increase Cardiff's chances of claiming one of the elusive runners-up positions.
Despite having lost all four games so far, the Ravens will be looking to end the group stages on a high note.
Newport will be hoping to keep alive their slim chances of clinching qualification when they lock horns with another French giant Toulouse.
Qualification for the last eight may be out of their hands following an agonising home defeat against Leinster, but Newport could still go through if they beat Toulouse and then Newcastle next week and other results are kind to them.
Swansea, who face Bath at St Helen's tomorrow, have delayed naming their side because of injury problems.
Wales lock Andy Moore has been ruled out with a neck strain while flanker Colin Charvis is doubtful.
The Whites have a mathematical chance of still qualifying but would have to run in five more tries than Bath following their 38-9 reverse at the Recreation Ground last October.
Wales duo Rhun Williams and Liam Belcher, who makes a welcome return after five months of injury woe, look ahead to next month's World Rugby U20 Championship in Manchester where they will face Ireland, Georgia and New Zealand.
Whenever Bedlinog tackle Penallta a massive fixure is guaranteed but this Sunday there will be even more emphasis placed on the two rivals when they contest the SSE Swalec Plate final at Principality Stadium.
Ahead of their SSE SWALEC Bowl Final clash with Taffs Well at Principality Stadium on Sunday, Burry Port share their #FABXV nomination with WRUTV in the search for Welsh rugby's greatest volunteers. Everyone can get involved by sending nominations via twitter to @WRU_Community using the hashtag #FABXV
Cardiff Blues prop Gethin Jenkins and Ospreys centre Ben John look ahead to the first game at Principality Stadium in Saturday's double header which is promising to be a special occasion for all Welsh fans.
Carmarthen Quins Director of Rugby Ian Jones and committee member Jeff Thomas along with Llandovery chairman Handel Davies look ahead to Sunday's SSE SWALEC Cup showdown where both teams are out to prove 'West is best'
SWALEC ambassador Shane WIlliams is looking forward to Sunday's Finals Day where the Cup, Bowl and Plate offers a great opportunity for players and teams to experience the magic of playing at Principality Stadium
Carmarthen Quins coach Richard Kelly believes it is an exciting time to be part of the Scarlets region as his side take on local rivals Llandovery in the SSE Swalec Cup final on Sunday, as WRU TV's Graeme Gillespie discovers