There have been several changes to the starting line up following their defeat to Australia on Monday.
Youngster Kerry Jenkins replaces scrum half Cath Walkley and Awen Thomas replaces Rhian Wilmott at fly half, who has struggled with injuries this season.
Catrin Edwards continues to impress in the front row and is joined by the familiar faces of Dawn Mason and Jamie Kift.
Claire Donovan has been dropped and April Dent moves from her usual position at No 8 to take her place in the second row. Kylie Wilson wears the No. 8 shirt with all-rounder Jackie Morgan at Flanker.
The backs remain the same with Flowers and Jones on the wings with captain Melissa Berry and Louise Rickard in the centre. Caernarfon's Kate Jones plays at full back.
Wales have to win by 21 points to secure the second place position in their pool. Germany lost their first round game to the favourites, New Zealand 117-0, so the Welsh squad are confident of victory this afternoon. The game kicks off at 4.30pm (local time)
1 Dawn Mason
2 Jamie Kift
3 Catrin Edwards
4 April Dent
5 Liza Burgess
6 Jackie Morgan
7 Pip Minto
8 Kylie Wilson
9 Kerry Jenkins
10 Awen Thomas
11 Sue Jones
12 Melissa Berry
13 Louise Rickard
14 Claire Flowers
15 Kate Jones
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series