It will be the biggest upset since David slew Goliath - or so say the bookies!
England are quoted at 1/33 to complete the Triple Crown against Wales at Twickenham on Saturday, with Scott Quinnell's side an incredible 10/1 against doing another 'Wembley'.
But what do the bookies know? It's what the real fans think that is important.
And on that score, 58% of the 4,000 people who answered our poll felt it is possible for the 'Mighty Quinn' and his red army to write another page in the rich history of Welsh rugby.
In fact, 2,329 of you voted for a Welsh success at the weekend, while 1,681 felt victory is beyond Scott and co.
I think Steve Hansen and his coaching team might take issue with the view of the latter group!
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series