With Cardiff almost assured of the title and with both Neath and Llanelli winning in midweek, a victory was needed by the Black and Ambers but despite an entertaining game the home side snatched the two points.
Wing Nathan Daniels scored a try for Newport while fly half Michael Hook added the conversion and a brace of penalties. Alan Williams, Shaun James and Daniel Povey scored tries for the home side while Michael Thomas added two conversions.
Newport are at home to second placed Neath on Tuesday evening (7.30)
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.