Though the two countries met in Buenos Aires in an eight-team tournament of 1999, in their Championship clashes, Wales won 36-21 at Neath in 1999; 15-12 at New Brighton in 2000 and 27-12 at Pontypridd last year.
After winning in Ireland and losing at home to France, Wales defeated Italy at Bridgend by 65-12, but nevertheless make several changes.
Liam Roberts switches wings for James Strong to make his debut, though he played in the 'A' team's draw with England 'A' at Pontypridd last December.
Andrew Powell, the powerful Newport forward is brought in at no 8, and Ryan Jones at lock, but the squad's only full international - Gavin Henson - is again on the replacements bench.
The overall Wales record in matches played in the Northern hemisphere is - Played 47, Won 36, Lost 11.
England's only victory against Wales was in their first meeting in 1998 at Worcester, winning 46-7.
Team: 15 Gareth Swales (Swansea); 14 James Strong (London Welsh), 13 Hal Luscombe (Newport), 12 Matthew Brayley (Swansea, capt), 11 Liam Roberts (Cardiff); 10 Nicky Robinson (Cardiff), 9 Michael Phillips (Llanelli); 1 Paul James (Neath), 2 Adam Matthews (Neath), 3 Adam Jones (Neath), 4 Luke Tait (Cardiff), 5 Ryan Jones (UWIC), 6 Rhys Williams (Ebbw Vale), 7 Gareth Williams (Llanelli), 8 Andrew Powell (Newport)Replacements: 16 Matthew Miles (Northampton), 17 Phil John (Llanelli), 18 Ceiron Jones (Llanelli), 19 Bryn Griffiths (Llanelli), 20 Rhys Jones (Newport), 21 Chris Miller (Cardiff), 22 Gavin Henson (Swansea).
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).
The winners of a filmmaking competition organised by the education charity Into Film and the WRU enjoyed a behind the scenes tour of the Millennium Stadium - and a chance to be photographed with the WRU's fire-breathing, rugby loving mascot, Scorch The Dragon, and Welsh international, Jake Ball.