Though the two countries met in Buenos Aires in an eight-team tournament of 1999, in their Championship clashes, Wales won 36-21 at Neath in 1999; 15-12 at New Brighton in 2000 and 27-12 at Pontypridd last year.
After winning in Ireland and losing at home to France, Wales defeated Italy at Bridgend by 65-12, but nevertheless make several changes.
Liam Roberts switches wings for James Strong to make his debut, though he played in the 'A' team's draw with England 'A' at Pontypridd last December.
Andrew Powell, the powerful Newport forward is brought in at no 8, and Ryan Jones at lock, but the squad's only full international - Gavin Henson - is again on the replacements bench.
The overall Wales record in matches played in the Northern hemisphere is - Played 47, Won 36, Lost 11.
England's only victory against Wales was in their first meeting in 1998 at Worcester, winning 46-7.
Team: 15 Gareth Swales (Swansea); 14 James Strong (London Welsh), 13 Hal Luscombe (Newport), 12 Matthew Brayley (Swansea, capt), 11 Liam Roberts (Cardiff); 10 Nicky Robinson (Cardiff), 9 Michael Phillips (Llanelli); 1 Paul James (Neath), 2 Adam Matthews (Neath), 3 Adam Jones (Neath), 4 Luke Tait (Cardiff), 5 Ryan Jones (UWIC), 6 Rhys Williams (Ebbw Vale), 7 Gareth Williams (Llanelli), 8 Andrew Powell (Newport)Replacements: 16 Matthew Miles (Northampton), 17 Phil John (Llanelli), 18 Ceiron Jones (Llanelli), 19 Bryn Griffiths (Llanelli), 20 Rhys Jones (Newport), 21 Chris Miller (Cardiff), 22 Gavin Henson (Swansea).
Nearly 40 players were involved in the first Wales Under 18 training session of the season. WRU National Performance Manager Gethin Watts is excited at the potential shown by the group and expects the Regional Under 18 Championship to hone their skills even further.
The WRU officially unveiled the new pitch today in time for Wales to take on Australia in the first of the Dove Men Series autumn international matches this Saturday. Head Groundsman Lee Evans and colleague Craig Campbell reflect on the 15-week project and look ahead to a pitch perfect future at Millennium Stadium.