Though the two countries met in Buenos Aires in an eight-team tournament of 1999, in their Championship clashes, Wales won 36-21 at Neath in 1999; 15-12 at New Brighton in 2000 and 27-12 at Pontypridd last year.
After winning in Ireland and losing at home to France, Wales defeated Italy at Bridgend by 65-12, but nevertheless make several changes.
Liam Roberts switches wings for James Strong to make his debut, though he played in the 'A' team's draw with England 'A' at Pontypridd last December.
Andrew Powell, the powerful Newport forward is brought in at no 8, and Ryan Jones at lock, but the squad's only full international - Gavin Henson - is again on the replacements bench.
The overall Wales record in matches played in the Northern hemisphere is - Played 47, Won 36, Lost 11.
England's only victory against Wales was in their first meeting in 1998 at Worcester, winning 46-7.
Team: 15 Gareth Swales (Swansea); 14 James Strong (London Welsh), 13 Hal Luscombe (Newport), 12 Matthew Brayley (Swansea, capt), 11 Liam Roberts (Cardiff); 10 Nicky Robinson (Cardiff), 9 Michael Phillips (Llanelli); 1 Paul James (Neath), 2 Adam Matthews (Neath), 3 Adam Jones (Neath), 4 Luke Tait (Cardiff), 5 Ryan Jones (UWIC), 6 Rhys Williams (Ebbw Vale), 7 Gareth Williams (Llanelli), 8 Andrew Powell (Newport)Replacements: 16 Matthew Miles (Northampton), 17 Phil John (Llanelli), 18 Ceiron Jones (Llanelli), 19 Bryn Griffiths (Llanelli), 20 Rhys Jones (Newport), 21 Chris Miller (Cardiff), 22 Gavin Henson (Swansea).
Dodgy tattoos, carthorses, Avatar and soft chins are revealed by Wales Sevens players Tom Williams and Sam Cross as they profile the Wales Sevens squad taking part in Hong Kong this weekend in the latest round of the HSBC Sevens World Series.
The youngest member of the Wales Women's squad, Keira Bevan, is hoping to repay the faith shown in her when she starts her first Six Nations game against Italy tomorrow evening in the final round of the championship.
Sevens head coach Gareth Williams is a happy man after drafting in full internationals Rhodri Williams and Adam Warren for the next two rounds of the world series in Hong Kong and Japan, as WRU TV's Graeme Gillespie discovers.