Though the two countries met in Buenos Aires in an eight-team tournament of 1999, in their Championship clashes, Wales won 36-21 at Neath in 1999; 15-12 at New Brighton in 2000 and 27-12 at Pontypridd last year.
After winning in Ireland and losing at home to France, Wales defeated Italy at Bridgend by 65-12, but nevertheless make several changes.
Liam Roberts switches wings for James Strong to make his debut, though he played in the 'A' team's draw with England 'A' at Pontypridd last December.
Andrew Powell, the powerful Newport forward is brought in at no 8, and Ryan Jones at lock, but the squad's only full international - Gavin Henson - is again on the replacements bench.
The overall Wales record in matches played in the Northern hemisphere is - Played 47, Won 36, Lost 11.
England's only victory against Wales was in their first meeting in 1998 at Worcester, winning 46-7.
Team: 15 Gareth Swales (Swansea); 14 James Strong (London Welsh), 13 Hal Luscombe (Newport), 12 Matthew Brayley (Swansea, capt), 11 Liam Roberts (Cardiff); 10 Nicky Robinson (Cardiff), 9 Michael Phillips (Llanelli); 1 Paul James (Neath), 2 Adam Matthews (Neath), 3 Adam Jones (Neath), 4 Luke Tait (Cardiff), 5 Ryan Jones (UWIC), 6 Rhys Williams (Ebbw Vale), 7 Gareth Williams (Llanelli), 8 Andrew Powell (Newport)Replacements: 16 Matthew Miles (Northampton), 17 Phil John (Llanelli), 18 Ceiron Jones (Llanelli), 19 Bryn Griffiths (Llanelli), 20 Rhys Jones (Newport), 21 Chris Miller (Cardiff), 22 Gavin Henson (Swansea).
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s