Stephen Jones is out of the Wales side to face England in the Lloyds TSB Six Nations match at Twickenham.
The Llanelli outside half has not recovered from the back spasms he suffered during the week and Iestyn Harris will take his place.
It will be the first time Harris has started a Lloyds TSB Six Nations match in his club position and he will be joined at half-back by his Cardiff partner Rob Howley.
Harris figured at centre in the opening championship match against Ireland and came on as a second half replacement full back against Italy.
Another Cardiff player, Nicky Robinson, has been brought onto the replacements bench to fill Harris' shirt. He was due to play for Wales Under 21 against England Under 21.
England have also had to make a change to their replacements. Sale Sharks outside half Charlie Hodgson has withdrawn through injury and Bath's Iain Balshaw has taken his place.
The SWALEC semi-final draws threw up some mouth-watering clashes in the Cup, Plate and Bowl as the 12 teams aim for the Millennium Stadium Finals Day. All the semi-finals are to be played on the weekend of April 12.
Welsh whistler Rhys Thomas continues to scale the heights of the game as he prepares to be an official in this weekend's Hong Kong Sevens tournament, undoubtedly the showpiece event on the World Series calendar.
Wales International Ian Evans and Wales and Lions legend Scott Quinnell swapped rugby balls for paint pots at Tonna during the RBS 6 Nations. They surprised club players with a special clubhouse makeover to launch NatWest RugbyForce 2014 - a programme developed in partnership with the WRU to make rugby clubs stronger businesses by improving and renovating their facilities with the support of volunteers and the local community.
Fresh from claiming the Bowl honours in Tokyo last Sunday, the Wales Sevens squad have settled into their routine as they prepare for this weekend's Hong Kong tournament where Iolo Evans is aiming high, as WRU TV's Graeme Gillespie discovers.
The Welsh Rugby Union has recently teamed up with Prostate Cymru to help the charity launch its latest campaign to raise awareness of the disease. Members of the Wales squad helped produce a short video and promotional material for the campaign titled 'The Best Defence - is to know the FACTS'.
Defending champions Coleg Sir Gar reached their second consecutive Millennium Stadium final as they defeated Coleg Gwent in the WRU Wednesday Under 18 play-off. Watch highlights of their narrow 10-8 win here.