Stephen Jones is out of the Wales side to face England in the Lloyds TSB Six Nations match at Twickenham.
The Llanelli outside half has not recovered from the back spasms he suffered during the week and Iestyn Harris will take his place.
It will be the first time Harris has started a Lloyds TSB Six Nations match in his club position and he will be joined at half-back by his Cardiff partner Rob Howley.
Harris figured at centre in the opening championship match against Ireland and came on as a second half replacement full back against Italy.
Another Cardiff player, Nicky Robinson, has been brought onto the replacements bench to fill Harris' shirt. He was due to play for Wales Under 21 against England Under 21.
England have also had to make a change to their replacements. Sale Sharks outside half Charlie Hodgson has withdrawn through injury and Bath's Iain Balshaw has taken his place.
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).
The winners of a filmmaking competition organised by the education charity Into Film and the WRU enjoyed a behind the scenes tour of the Millennium Stadium - and a chance to be photographed with the WRU's fire-breathing, rugby loving mascot, Scorch The Dragon, and Welsh international, Jake Ball.