Stephen Jones is out of the Wales side to face England in the Lloyds TSB Six Nations match at Twickenham.
The Llanelli outside half has not recovered from the back spasms he suffered during the week and Iestyn Harris will take his place.
It will be the first time Harris has started a Lloyds TSB Six Nations match in his club position and he will be joined at half-back by his Cardiff partner Rob Howley.
Harris figured at centre in the opening championship match against Ireland and came on as a second half replacement full back against Italy.
Another Cardiff player, Nicky Robinson, has been brought onto the replacements bench to fill Harris' shirt. He was due to play for Wales Under 21 against England Under 21.
England have also had to make a change to their replacements. Sale Sharks outside half Charlie Hodgson has withdrawn through injury and Bath's Iain Balshaw has taken his place.
The WRU has teamed up with Crawshay's to tour Georgia in June. The side, which will be called the Crawshays WRU President's XV, will play Emerging Georgia twice, in a tour which supports the Welsh Government's efforts to grow relations between the two countries.
Wales Sevens are looking to re-group after a disappointing tournament last time out in South Africa. The next double leg in New Zealand and Las Vegas offers Gareth Williams a chance to redeem themselves.
Wales Women's head coach Rhys Edwards was at Llandovery to see the conclusion of an entertaining Women's Regional championship where any one of three teams were in contention for title glory on the last day of action.
Christmas has come early at Glynneath rugby club, one of a number around Wales who have received an array of merchandise and equipment this December courtesy of the Welsh Rugby Union's £750,000 participation points scheme.
The WRU have been delivering on the scheme - which gives individual clubs access to up to £5,000 worth of supplies and equipment each for the 2014/2015 season - over the last two weeks and today (Friday) were received by a special guest in Glynneath, club president and pitch marker Max Boyce.