To complete the raft of changes, Jerome Kaino will play blindside flanker in place of Victor Vito's.
Injury has largely forced the hand of All Blacks coach Graham Henry with star man Dan Carter still under an injury cloud. The fly half is still struggling with a calf injury.
Full-back Israel Dagg (concussion) and lock Anthony Boric (cheekbone) drop out with Muliaina and Donnelly taking over with both having recovered from calf injuries. Eye injury victim Conrad Smith sees Kahui take his place at centre.
Henry said: "We were forced to make changes. There's a lock injured, there's a centre injured and there's a full-back injured.
"There was a guy playing tight-head prop who's a youngster - he's 22 and has played in the last two Test matches and we don't think it's a good thing for him to play three in a row.
"So most of the changes have been forced on us. We haven't selected a side because we're playing Wales in the second Test and we won the first one 42-9. We've selected what we thought was the best team we can select.
"I think it's a balanced selection, a strong team. The two prop changes - our most experienced props were our first-choice props last year.
"The lock change - Tom Donnelly was our first-choice lock with Brad Thorn at the end of year tour and he comes back in after injury.
"Jerome Kaino has been our number one six for a long time and he comes back in Victor Vito's place - he played very well last week - but Jerome had a bit of a calf muscle problem last week so we thought it best to rest him.
"It appears like there are a lot of changes, but the changes are logical and mostly because of injury."