Parks will leave from the historic Pierhead building in Cardiff Bay - one hundred years after the British Antarctic Expedition, led by Captain Robert Falcon Scott, departed from Cardiff Bay in the vessel SS Terra Nova.
"Richard leaves Cardiff for the biggest challenge of his life this weekend and I express the sentiments of everyone at the Welsh Rugby Union in wishing him all the very best over the next seven months," said WRU Head of Communications John Williams.
"The Welsh public showed overwhelming support for Richard at the Wales v New Zealand match last month and we all hope that we can welcome Richard back to the Millennium Stadium on completion of this phenomenal challenge."
Richard will enter the record books as the first person to stand on all seven summits and the two poles in the same year, making his achievement a true 'World First' on completion of the challenge.
As well as giving Richard a rousing send-off at the sell-out Invesco Perpetual clash against New Zealand on Saturday, 27 November at the Millennium Stadium last month, Welsh rugby fans have followed the former Welsh rugby player's training progress on the WRU website.
WRU TV's latest video celebrates his the 737 Challenge Gala Dinner at the National Museum which that raised a total of 9,819 for Marie Curie Cancer Care.