Three South East side Brecon have been handed a tricky home tie against Tylorstown of Two East, but as the visitors are struggling in the league, the Parc de Pugh club could boost their season with a surprise victory.
North Wales sides Ruthin and Mold meet at Cae Ddol and in the recent league meeting, the win went Mold's way after a 27-25 success. Mold are still unbeaten in the league but Ruthin could turn the tables in this cup tie.
Tondu will be expecting to take their league form into the cup when they entertain Heol y Cyw of Three South East. The Waterwheelers are well placed in Two West but their visitors are only one point off the pace in their division and they are sure to make life difficult for their hosts.
Ties to be played weekend of 29 January, 2011
Ammanford v Penclawdd / Morriston
BP Llandarcy / Aberavon Quins v Ystalyfera / Glynneath
Brecon v Tylorstown
Croesyceiliog / Pontypool Utd v Abergavenny / Brynmawr
Kidwelly / Crymych v Llanelli Wanderers / Laugharne
Lampeter / Aberystwyth v Pontyberem / Newcastle Emlyn
Llantwit Fardre v Mountain Ash
Nant Conwy / Llangefni v Pwllheli / Caernarfon
Penarth v Risca / Gwernyfed
Pill Harriers v Tredegar Ironsides / Newport HSOB
Rhymney / Blaina / Ynysybwl v Penallta
Ruthin v Mold
Seven Sisters / Skewen v Bryncoch / Cwmavon
Taffs Well / Dowlais v Llandaff North / Aberdare
Tondu v Heol y Cyw
Tumble / Loughor v Gorseinon / Dunvant