Alain Rolland will take charge of Wales' opening Six Nations clash with England in Cardiff on Friday, February 4, while fellow Irishman George Clancy, England's Wayne Barnes and the South African pair of Jonathan Kaplan and Craig Joubert will also take charge of games involving Wales.
The appointments were made by the IRB Match Official Selection Committee at its meeting in Dublin this week following a comprehensive review of international referee, assistant referee and television match official performances during the recent November Tests.
With the Rugby World Cup 2011 in New Zealand less than 10 months away the appointments will give the world's top referees a further chance to cement their place in the IRB Panel for Rugby's global showcase tournament.
The selection also sees Steve Walsh take charge of his first Six Nations match since 2008 when he referees England versus France at Twickenham on February 26. In total there are 10 Referees selected for the 15 Championship matches.
"We are beginning the countdown towards Rugby World Cup 2011 and a streamlined panel of 10 top referees who will officiate at the tournament," said IRB Match Official Selection Committee Chairman and IRB Council Member David Pickering.
"However, there are still 10 months to go until the showcase tournament kicks off and there is plenty of time for places to be secured. We have worked hard on consistency across the board and referees and coaches have universally bought into the strict application of five key areas of Law."
"Collectively we are focused on further promoting consistency across all areas of officiating to ensure that those selected for Rugby World Cup 2011 are the best and that they will be in peak physical and performance condition for what promises to be a special tournament," added Pickering.