Wales will face New Zealand in front of a capacity 74,500 crowd at the Millennium Stadium on November 27 after tickets for the Invesco Perpetual Series closing international match sold out.
Tickets still remain available for the opening game against Australia this Saturday (KO 2.30), South Africa on November 13 (KO 2.30) and Fiji on November 19 (KO 7.30).
The WRU Group Sales and Marketing Manager, Craig Maxwell, said: "We are delighted at the response from supporters for the New Zealand match which is great news for the Millennium Stadium.
"Interest in all four of our games has been growing steadily and this week there has been huge media focus on the series. We have a great series of matches in prospect here in Cardiff and we know the interest is going to continue to build in the weeks ahead as well.
"We were always confident it was only a matter of time before the New Zealand game sold out and the fans have proved us right.
"There are still some tickets available for the other matches so supporters will still have a chance to watch Wales play.
"The tickets for the Australia game are now selling very well but supporters will still be able to come along on Saturday and buy tickets from our outlet in the Cardiff Arms cafe and store on Westgate Street just outside the Stadium at entrance 3."
You can get tickets for Wales' Autumn internationals by calling: 08442 777888 or call in at the Cardiff Arms Store, 8 Westgate Street, Cardiff or visit www.wru.co.uk/tickets
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.