Ospreys prop James starts in the front row after Jenkins failed a late fitness test on a calf problem this morning.
Powell is replaced on the bench by Blues lock Deiniol Jones, meaning Ryan Jones is now the main back row cover and will therefore wear '19' with his namesake now in possession of the number '18' jersey.
Blues prop John Yapp also comes onto the replacements bench, in place of the promoted James.
Wales:15 Lee Byrne, 14 George North, 13 Tom Shanklin, 12 James Hook, 11 Shane Williams, 10 Stephen Jones, 9 Mike Phillips, 8 Jonathan Thomas, 7 Martyn Williams, 6 Andy Powell, 5 Bradley Davies, 4 Alun-Wyn Jones, 3 Adam Jones, 2 Matthew Rees 1 Paul James.
Replacements: 16 Huw Bennett, 17 John Yapp, 18 Deiniol Jones, 19 Ryan Jones, 20 Richie Rees, 21 Andrew Bishop, 22 Chris Czekaj.
South Africa:15 Gio Aplon, 14 Bjorn Basson, 13 Frans Steyn, 12 Jean de Villiers, 11 Bryan Habana, 10 Morne Steyn, 9 Ruan Pienaar, 8 Pierre Spies, 7 Juan Smith, 6 Deon Stegmann, 5 Victor Matfield (capt), 4 Bakkies Botha, 3 Jannie du Plessis, 2 Bismarck du Plessis, 1 Tendai Mtawarira,
Replacements: 16 Chiliboy Ralepelle, 17 CJ van der Linde, 18 Flip van der Merwe, 19 Willem Alberts, 20 Francois Hougaard, 21 Zane Kirchner, 22 Patrick Lambie.






