Newport, the strongest Welsh team in last season's British & Irish Cup welcome Leinster to Rodney Parade on Sunday in their first match in this year's competition.
The Black and Ambers came the closest of the Welsh sides to qualifying for last season's semis but went down to eventual winners Cornish Pirates in the last round of pool games.
Head coach Sven Cronk hopes that experience will give his side heart ahead of this campaign, saying: "We felt we were a bit unlucky not to beat Cornish Pirates last season but we can't look back, we have to use that to build towards this season.
"We wholeheartedly embrace this competition and we're looking forward to getting started against Leinster who are a mix of young academy players and experienced Leinster players.
"This competition is certainly a step-up for us. You get limited scoring opportunities that you have to take and your defence needs to be spot on too.
"We have a number of injuries at the moment but we have been strengthened this week by some Dragons squad players such as Lewis Evans, Adam Jones and Nicky Griffiths and we know the Dragons management will be watching the game to see who performs well.
"The addition of the quarter-final stage means two teams can qualify from each group, which is an extra incentive for all participants."
These weekend's Round 5 matches were scheduled for the weekend of February 26 but have been brought forward to avoid clashing with RBS 6 Nations fixtures.
All other clubs in the competition enter on the weekend of December 11 with the regular Round One fixtures.
British & Irish Cup Round 5
Friday, October 15, 2010
Pool B Munster v Llanelli 19:30 Waterford Regional Sports Centre
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.