"We've asked the boys to put Pontypool behind us, take the positives forward and put in a performance," added manager Darren Joy.
For the challenge of Newport the Wanderers welcome back experience and talent. Wales Under 20's captain Josh Navidi and full back Dan Fish are released to start for the first time this season.
They are joined by experienced second row Alex Luff who has recovered from a pre-season injury. Matt Bolton also gives a start to Mike Hurley and Elliot Jones in the backs whilst Darragh Cantillon replaces Mark O'Leary in the front row.
Another academy player Luke Hamilton joins the squad on the replacements bench.
Glamorgan Wanderers: 15. Dan Fish 14. Rory Budina 13. Robin Lock 12. Mike Hurley 11. Elliot Jones 10. Tomas Marks 9. Harry Trelawny (Capt); 1. Marc Thomas 2. Mark Sheppard 3. Darragh Cantillon 4. Alex Luff 5. Jan Botes 6. Nick Hampson 7. Josh Navidi 8. Carl Kimber
Subs: 16. Rhys Blumberg 17. Mark O'Leary 18. Gareth Tedstone 19. Richard Thomas 20. Luke Hamilton 21. Tom Rowlands 22. Owen Marshall