"Both sides are looking for that confidence boost after difficult opening games and the Drovers are a strong side at home," said Wanderers coach Chris Ower before the trip to Llandovery.
"We need to get on a winning run after conceding so many points in our opening games" he added.
Manager Darren Joy, commented "This early in the season a game with so much riding on it is rare but the squad is in good spirit and looking forward to the challenge"
After the humiliating defeat at Sardis Road the Wanderers make 12 changes to their starting line-up. Dan Fish, Gareth Morris, Tomas Marks and Harry Trelawny all return to strengthen the back division and the whole of the pack is changed from Wednesday night with the inclusion of Luke Hamilton and Josh Navidi in the back row and Blues players Ben White and Bryn Griffiths having a run out to get some match fitness.
Reuben Tucker who has impressed everyone this season starts from the bench.
Glamorgan Wadnerers 15. Dan Fish 14. Rory Budina 13. Robin Lock 12. Gareth Morris 11. Elliot Jones 10. Tomas Marks 9. Harry Trelawny (Capt); 1. Marc Thomas 2. Mark Sheppard 3. Mark O'Leary 4. Alex Luff 5. Bryn Griffiths 6. Ben White 7. Josh Navidi 8. Luke Hamilton
Replacements: 16. Ryan Prosser 17. Darragh Cantillon 18. Gareth Tedstone 19. Reuben Tucker 20. Jaen Botes 21. Tom Rowlands 22. Ceri Llewelyn