Up front Nick Hampson comes in at open-side, for his first game of the season, following his transfer in the summer from Cardiff and South African Jaen Botes replaces John Barley in the second row.
"Pontypool have had a decent start to the season and with Shaun Connor at 10 they have a massive player of influence," commented Wanderers coach Chris Ower.
"Once again we are looking for improvement from our young side," added manager Darren Joy.
Glamorgan Wanderers 15. Owen Marshall 14. Rory Budina 13. Gareth Morris (C) 12. Robin Lock 11. Ryan Healey 10. Tomas Marks 9. Tom Rowlands; 1. Marc Thomas 2. Mark Sheppard 3. Mark O'Leary 4. Richard Thomas 5. Jaen Botes 6. Reuben Tucker 7. Nick Hampson 8. Carl Kimber
Subs: 16. Ryan Prosser 17. Darragh Cantillon 18. Gareth Tedstone 19. Josh Sheehan 20. Ed Morris 21. Harry Trelawny 22. Lewis Johnson