Hard running centre Adi Taviner will captain Wales U20s against England.
Wales Women Under 20s are hoping to turn the tables on arch rivals England in an international clash at Taffs Well on Sunday (KO 2pm).
The red rose brigade had to dig deep to repel the challenge of Wales two weeks ago to scrape home with a 17-7 victory. Kylie Wilson's team are determined to build on their excellent first half performance from last time out but will have to turn pressure into points if they are to reverse the result.
Wales coach Wilson, said: "The coaching team are excited to see some new players enter the squad, confirming the improved depth at this age group within Wales through the new regional programme.
"[Utility back] Megan Williams was identified through the Dragons and will be keen to earn her first cap."
Williams, along with fellow replacements Natalie Stone and Rebecca Norris will earn their first Welsh caps if they get off the bench.
Half of the Welsh squad will be playing their last game at this level before moving up to the senior ranks. With just one more round of regional games remaining before Jason Lewis announces his World Cup squad, Sunday's encounter offers the players a chance to impress.
Wales have selected a physical pack to combat the strong English unit while the backline has been re-shuffled after centre Jess Smith was ruled out due to injury.
Jess Kavanagh comes in at wing with Charlotte Murray moving to outside centre while captain Adi Taviner shifts to inside centre.
Wales manager Sara Davies, said: "Many of the players will be playing their last game at U20 level so they will be determined to leave on a high and put in a performance that earns Wales their first victory over the old enemy at this level.
"Some may have one eye on World Cup selection so that will ensure they give 100 per cent so hopefully that will inspire them to a victory," she added.
Wales Women's Under 20s
15 Kerin Lake (Neath Athletic)
14 Sian Perry (Altrincham Kersal)
13 Charlotte Murray (Neath Athletic)
12 Adi Taviner (Neath Athletic)
11 Jess Kavanagh (Dolgellau)
10 Bethan Preece (Neath Athletic)
9 Yasmin Leung (UWIC)
1 Alex Stokes (Neath Athletic)
2 Amy Lawrence (Neath Athletic)
3 Lowri Harris (UWIC)
4 Chloe Howells (Whitland)
5 Shona Powell-Hughes (Neath Athletic)
6 Sian Williams (RAF)
8 Vicky Owens (UWIC)
7 Sioned Harris (UWIC)
16 Natalie Stone (Pontyclun)
17 Sophie Mangano (Kidwelly)
18 Rebecca Norris (Carmarthen Quins)
19 Kathryn Joseph (Neath Athletic)
20 Kayleigh Balchin (Longton)
21 Megan Williams (OA Saints)
22 Rhianydd Morgan (Neath Athletic)
England Under 20s 15 Kay Wilson (Richmond) 14 Rebecca Hughes (Bristol) 13 Amy Wilson Hardy (Hove) 12 Amber Reed (Bristol) 11 Sophie Watkiss (Worcester) 10 Emily Scott 9 Fiona Davidson (Richmond); 1 Sasha Acheson (Shelford) 2 Vicky Fleetwood (Lichfield) 3 Charlotte Male (Bristol - capt) 4 Amy Millar (Worcester), 5 Stacey Maguire (Lichfield), 6 Poppy Cleall (Ellingham & Ringwood), 7 Hannah Field (Wasps), 8 Nicola Hoole (Bristol).
Replacements: 16 Geraldine Thomas (OA Saints), 17 Mille Fuggles (OA Saints), 18 Sarah George (Univeristy of Exeter), 19 Marlie Packer (Bristol), 20 Hannah Gallagher (Saracens), 21 Jessie flowers (Oxford University), 22 Garnet Mackinder (Lichfield).
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series