Gavin Thomas, who has been outstanding since joining the Dragons from the Scarlets, will be looking to impress again against the Ospreys.
Paul Turner has announced a 25 man squad in preparation for Friday evening's Magners League match with the Ospreys at the Liberty Stadium (KO 7:05pm).
Looking forward to the Dragons final game of the season head coach Paul Turner said: "Many of the young players included in the squad are our future and have a great opportunity to press their cases. We've been really pleased with the likes of Andrew Coombs and Lloyd Burns who have stepped up to the plate this season, gaining valuable experience.
"We have a great environment for youngsters here, the new training facility is excellent and real progress is being made. The players that have stuck with us have shown real improvement and are being well coached.'"
Dragons captain Tom Willis is relishing the prospect of another Welsh derby.
''It would be great to finish the season with another big scalp, but we understand that they will be hurting from what happened to them here back in March. There's no doubt that they will put out a strong team. But we have fought hard this season to gain respect and we don't want to throw that away this weekend.
"This league is about squads, but we have been well supported by the Principality Premiership teams in our Region, and the Academy have played a significant role too.
'We're happy with direction we are going and we're going at a good speed. There are still things to work on, such as our away form, but overall we're on the right track.'
Scrum-half, Wayne Evans added 'The Ospreys present another great opportunity to perform against some class players.
Backs: Adam Hughes, Will Harries, Rhodri Gomer Davies, Pat Leach, Richard Fussell, Jason Tovey, Lewis Robling, Jonathan Evans, Adam Greendale, Wayne Evans, Tom Riley, Matthew Pewtner
Forwards: Lewis Evans, Pat Palmer, Tim Willis, Toby Faletau, Andrew Coombs, Hoani MacDonald, Ben Castle, Rob Sidloi, Gavin Thomas, Lloyd Burns, Jevon Groves, Aaron Coundley, James Harris.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series