A foot injury will put Gethin Jenkins out of service when the Cardiff Blues' take on Newport Gwent Dragons on Friday in the Magners League
The British and Irish Lions prop is a confirmed absentee but there are also doubts over Wales flanker Martyn Williams (ribs), hooker Gareth Williams (shoulder) and former New Zealand centre Casey Laulala (knee) are also doubts for the Blues.
Dragons wing Aled Brew is a doubt as he bids to recover from an ankle injury.
While lock Adam Jones and flanker Dan Lydiate are out for the season but centre Ashley Smith could return.
Dai Young's men will also be without Wales duo scrum-half Gareth Cooper and centre Tom Shanklin due to injury.
And Wales wing Tom James is definitely out injured for the Blues while number eight Andy Powell has recovered from a calf injury.
While Blues lock Deiniol Jones is set to break the Magners League appearance record as his 118th league game would eclipse Dragons prop Adam Black's record.
The Blues hope to extend their winning run over the Dragons to seven games although the Rodney Parade region have only lost once at home this season - to another Welsh region Llanelli Scarlets.
The Cardiff side are bidding for their fifth successive victory and hoping to extend their impressive form of six successive wins in all competitions.
The Dragons and Blues have already qualified for the Heineken Cup next season but both are chasing an outside spot for the top-four end-of-season play-off.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.
Wales Sevens head coach Gareth Williams looks back on the Rio Sevens success where he helped GB win silver. He believes the successful campaign is a huge boost to his Welsh squad as they prepare for another World Series, as WRU TV's Graeme Gillespie discovers
British and Irish Lions head coach Warren Gatland will be heading back home to take on the All Blacks next year where for him, success for 2017 is all about going to New Zealand and winning a Test Series.
Last week all roads led to Eugene Cross Park where defending champions Ebbw Vale hosted this season's launch of the Principality Premiership. WRU TV's Graeme Gillespie was there to capture the thoughts of Damien Hudd, captain of Ebbw Vale, and WRU Head of Performance, Geraint John.
Llandovery made it three in a row when they defeated Aberavon in the final of the National Foster's 7s at BT Sport Cardiff Arms Park on Sunday. On another eventful day of sevens, Newport claimed the Plate and the Dragons won the women's crown
Last week saw Cardiff welcome players from around the world for the 21st Golden Oldies Festival. The tournament features players over 35 years of age, and this year's event saw a select few represent the WRU in a 'friendly' against the Wooden Spoon.
Wales Under 18 captain Callum Bradbury is delighted to have seen his side claim a narrow 18-17 victory against a strong SA Schools 'A' side to end the three-match Under 19 International Series in South Africa on a high note.
The Wales U18 squad spent an emotional day in the drug-riddled townnship of Hout Bay. Hout Bay Warriors President Fred Johannes said the visit was 'the talk of the town' and will dream about the day everyday for the rest of his life.
RGC 1404's new head coach Mark Jones is hoping to build 'something special' in north Wales and is already looking forward to the development region participating in the Principality Premiership for the very first time.