A foot injury will put Gethin Jenkins out of service when the Cardiff Blues' take on Newport Gwent Dragons on Friday in the Magners League
The British and Irish Lions prop is a confirmed absentee but there are also doubts over Wales flanker Martyn Williams (ribs), hooker Gareth Williams (shoulder) and former New Zealand centre Casey Laulala (knee) are also doubts for the Blues.
Dragons wing Aled Brew is a doubt as he bids to recover from an ankle injury.
While lock Adam Jones and flanker Dan Lydiate are out for the season but centre Ashley Smith could return.
Dai Young's men will also be without Wales duo scrum-half Gareth Cooper and centre Tom Shanklin due to injury.
And Wales wing Tom James is definitely out injured for the Blues while number eight Andy Powell has recovered from a calf injury.
While Blues lock Deiniol Jones is set to break the Magners League appearance record as his 118th league game would eclipse Dragons prop Adam Black's record.
The Blues hope to extend their winning run over the Dragons to seven games although the Rodney Parade region have only lost once at home this season - to another Welsh region Llanelli Scarlets.
The Cardiff side are bidding for their fifth successive victory and hoping to extend their impressive form of six successive wins in all competitions.
The Dragons and Blues have already qualified for the Heineken Cup next season but both are chasing an outside spot for the top-four end-of-season play-off.
The WRU's Women and Girls legacy events - #TRY OUR GAME have proved popular this week with current players and newcomers to the game learning new skills and picking up tips from national squad players.
We caught up with Shona and Ellie from the Wales women team ahead of the start of the Women's Rugby World Cup in Paris next month at a recent women's training session to encourage and promote more women and girls to try their hand at rugby. #tryourgame
The Women's Rugby World Cup warm-up clash between Wales and USA proved bittersweet for centre Elen Evans. Despite being one of the star performers on the day on her 50th Test appearance, USA edged home 10-7 at Cross Keys.
Wales completed their Junior World Championship campaign with a victory over Samoa. Team manager Mark Taylor and No 8 James Benjamin reflect on a tournament which saw Wales win three games and lose two.
Wales U20 players Angus O'Brien, Nicky Thomas and coach Richard Hodges are determined to finish their Junior World Championship with a flourish when they tackle the big hitting Samoans tomorrow in Auckland.