A foot injury will put Gethin Jenkins out of service when the Cardiff Blues' take on Newport Gwent Dragons on Friday in the Magners League
The British and Irish Lions prop is a confirmed absentee but there are also doubts over Wales flanker Martyn Williams (ribs), hooker Gareth Williams (shoulder) and former New Zealand centre Casey Laulala (knee) are also doubts for the Blues.
Dragons wing Aled Brew is a doubt as he bids to recover from an ankle injury.
While lock Adam Jones and flanker Dan Lydiate are out for the season but centre Ashley Smith could return.
Dai Young's men will also be without Wales duo scrum-half Gareth Cooper and centre Tom Shanklin due to injury.
And Wales wing Tom James is definitely out injured for the Blues while number eight Andy Powell has recovered from a calf injury.
While Blues lock Deiniol Jones is set to break the Magners League appearance record as his 118th league game would eclipse Dragons prop Adam Black's record.
The Blues hope to extend their winning run over the Dragons to seven games although the Rodney Parade region have only lost once at home this season - to another Welsh region Llanelli Scarlets.
The Cardiff side are bidding for their fifth successive victory and hoping to extend their impressive form of six successive wins in all competitions.
The Dragons and Blues have already qualified for the Heineken Cup next season but both are chasing an outside spot for the top-four end-of-season play-off.
WRU International Skills Coach Jason Strange is a busy man, combining the new role with that of Wales Under 20 attack coach, Ebbw Vale head coach and continuing to teach at Ebbw Fawr Learning Community.
Warren Gatland and Sam Warburton look ahead to this week's crunch RBS 6 Nations tie against France, where the Wales skipper in particular is keen to make his mark, as Paris has proved a bleak place for him in the past.
Following their historic win over England, Wales Under 20 suffered a narrow, 36-34 loss to their Scottish counterparts last weekend, despite outscoring them by five tries to three. Watch the match highlights and reaction.
WRU TV go behind the scenes with the Wales squad as they put the final touches in place ahead of the clash against Scotland at Murrayfield. Follow the squad on their captain's run, the kickers visit to Murrayfield and Neil Jenkins' press conference