Neath Head Coach Patrick Horgan, said: "There is no doubt that Pontypridd will provide one of our toughest challenges at The Gnoll this season.
"They are building towards a Cup semi-final against Carmarthen Quins and Paul John and Dale McIntosh will have them geared for a big effort. We know they rested a lot of players in midweek against Ebbw Vale so we expect a full-on challenge.
"There is still a long way to go in this League campaign and, despite beating Swansea convincingly, we haven't won anything yet - this game really is crucial to our prospects."
"After taking charge of the Dragons-Ospreys match last week, Wales' top referee Nigel Owens is in charge and he always accentuates the positive so the game should be a good spectacle and a big crowd is expected.
"Our boys have worked hard to get where we are and, if we can maintain our approach, we will deserve success."
Neath G.King; K.James, S.Thomas, N.Brew, K.Phillips; A.Thomas (captain), K.Farrell; A.V.Lott, A.James, M.Jones; E.Evans, N.Edwards; G.Gravell, L.Evans, S.Tandy
Replacements : A.Jenkins, G.McCarthy, R.Jones, E.Lewis, G.Price, P.Sidoli, M.Collins