There was also a hat-trick for Stephen Thomas and a brace for Alec Jenkins and Gerwyn Price. Gareth Gravell, Kevin Farrell, Nathan Brew, Gareth King, Neil Edwards and Ashleigh James completed the scoring on a historic day for Neath, who still have a game to play.
Gareth McCarthy knocked over seven conversions while Arwel Thomas collected five.
Ebbw Vale's fate at the bottom may already have been sealed, but they produced a spirited performance to see off Glamorgan Wanderers, 36-30. Prop Aaron Coundley scored a marvellous hat-trick, while there were also touchdowns for lock Nick Eaves and centre Lloyd Phillips.
Youngster Joe Xibberas scored a brace for the Wanderers but it was not enough to prevent them from falling to another defeat.
In the only other Premiership game, Aberavon crossed eight times in beating Pontypool 60-27. Wing Chris Morgan scored a hat-trick, his partner on the other wing Mark Bennett scored a brace and Ashley Beck, Neil White and Christian Richards also crossed as the home side eased to victory.