Glamorgan Wanderers travel to the Gnoll for the second time in a month on Saturday
"We expect a backlash after putting them out of the cup but we need our heads to rule our hearts and blank out all the off the field nonsense," commented coach Richard Hodges on the challenge ahead.
"Currently top of the Principality Premiership, Neath will be concentrating on winning back the league title now after their exit from the cup."
The Wanderers will be looking to bounce back after the home defeat to Cross Keys with Dan Fish, Josh Navidi and Ieuan Davies involved with the Wales Under 20s Hodges shuffles his squad again.
Owen Marshall starts at 15 and Harry Trelawny returns as captain at scrum half in a back division that shows two changes from the side that beat Neath. In the pack a late decision will be made in the front row but Jim Richards returns at hooker on a ground that has many memories for him.
Lee Highgate, Ben Rose and Mazin Al-Azzawi continue in the back row and Mark O'Leary returns after intense physio treatment on his shoulder injury.
Glamorgan Wanderers 15. Owen Marshall 14. Steve Cullen 13. Simon Rosser 12. Charlie Johnson 11. Rory Budina 10. Scott Sneddon 9. Harry Trelawny; 1. Mark O'Leary 2. James Richards 3. Danny Douthwaite/ Ryan Beddows 4. Gareth Knight 5. John Barley 6. Lee Highgate 7. Ben Rose 8. Mazin Al-Azzawi
Replacements: 16. Ieuan Dobbs 17. Ryan Beddows / Danny Douthwaite 18. Richard Thomas 19. A.N.Other 20. Ross Wardle 22. Rhys Dyer 24. Ryan Healey
WRU International Skills Coach Jason Strange is a busy man, combining the new role with that of Wales Under 20 attack coach, Ebbw Vale head coach and continuing to teach at Ebbw Fawr Learning Community.
Warren Gatland and Sam Warburton look ahead to this week's crunch RBS 6 Nations tie against France, where the Wales skipper in particular is keen to make his mark, as Paris has proved a bleak place for him in the past.
Following their historic win over England, Wales Under 20 suffered a narrow, 36-34 loss to their Scottish counterparts last weekend, despite outscoring them by five tries to three. Watch the match highlights and reaction.
WRU TV go behind the scenes with the Wales squad as they put the final touches in place ahead of the clash against Scotland at Murrayfield. Follow the squad on their captain's run, the kickers visit to Murrayfield and Neil Jenkins' press conference