Glamorgan Wanderers travel to the Gnoll for the second time in a month on Saturday
"We expect a backlash after putting them out of the cup but we need our heads to rule our hearts and blank out all the off the field nonsense," commented coach Richard Hodges on the challenge ahead.
"Currently top of the Principality Premiership, Neath will be concentrating on winning back the league title now after their exit from the cup."
The Wanderers will be looking to bounce back after the home defeat to Cross Keys with Dan Fish, Josh Navidi and Ieuan Davies involved with the Wales Under 20s Hodges shuffles his squad again.
Owen Marshall starts at 15 and Harry Trelawny returns as captain at scrum half in a back division that shows two changes from the side that beat Neath. In the pack a late decision will be made in the front row but Jim Richards returns at hooker on a ground that has many memories for him.
Lee Highgate, Ben Rose and Mazin Al-Azzawi continue in the back row and Mark O'Leary returns after intense physio treatment on his shoulder injury.
Glamorgan Wanderers 15. Owen Marshall 14. Steve Cullen 13. Simon Rosser 12. Charlie Johnson 11. Rory Budina 10. Scott Sneddon 9. Harry Trelawny; 1. Mark O'Leary 2. James Richards 3. Danny Douthwaite/ Ryan Beddows 4. Gareth Knight 5. John Barley 6. Lee Highgate 7. Ben Rose 8. Mazin Al-Azzawi
Replacements: 16. Ieuan Dobbs 17. Ryan Beddows / Danny Douthwaite 18. Richard Thomas 19. A.N.Other 20. Ross Wardle 22. Rhys Dyer 24. Ryan Healey
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