Gethin Jenkins leaves the field against Scotland last Saturday.
Wales physio Mark Davies has today confirmed Matthew Rees, Gethin Jenkins and Gareth Williams will all be unavailable for selection for the RBS 6 Nations clash with France at the Millennium Stadium a week on Friday (Kick-off 8pm)
Scarlets hooker Rees has failed to recover from a groin problem, Blues prop Gethin Jenkins has a calf injury and fellow Blues player, hooker Gareth Williams, has damaged knee ligaments.
"Matthew (Rees) is progressing well and will continue his rehab in camp with Wales," said Davies.
"He will undergo exhaustive testing over the next few days which will give us a clearer idea of when he may be available, but we can confirm that the France game will come too soon for him.
"Gethin (Jenkins) has been scanned since leaving the field against Scotland and, as we thought, he has aggravated the calf injury which kept him out against England. At this stage we are not putting a time limit on his recovery, but again we know he will not take the field against France.
"Gareth (Williams) sustained medial ligament damage to his knee during the win over Scotland last weekend. He will undertake a rest and rehab programme and his progress will be re-assessed next week, but the injury rules him out of contention for Friday night."
The Wales Women's team headed to Dare Valley Country Park on a team bonding exercise as the entire squad got together for the very first time in preparation for this season's Six Nations championship which kicks off on Saturday with a clash against defending champions Ireland, in Donnybrook.
Wales Head Coach Warren Gatland discusses his team selection for the opening round of the RBS 6 Nations where he leads his side against Ireland, on Sunday. As WRU TV's Luke Brodley discovers, Gatland is fully aware of the challenges the defending champions pose
WRUTV caught up with Wales Women captain Rachel Taylor at the RBS 6 Nations launch and how a good crowd really helps boost the girls performance. Tickets for all three Women's home games at The Gnoll, Neath are available from www.wru.wales/tickets