The title favourites were 36-16 winners at Tredegar back in October and have since swept all before on the way to a final showdown with either the Ospreys or Blues South.
Leading scorer and outside half Jordan Williams is named in a back line that also includes the likes of scrum half Connor Lloyd and centre Steff Hughes.
The Dragons, who have won only twice this season, will be keen to sign off with a morale boosting away success but will find it tough against a cock a hoop Scarlets side who have been far and away the stand out side in this season's Championship.
Scarlets: W Lewis; D Morgans, S Hughes, G Owens, R James; J Williams, C Lloyd; B Davies, T Ball, G Davies, T Morrisey, C Marks, S Bennett, D Thomas, J Williams. Replacements: R Davies, D Havard, D Morgan, D Doughty, G George, S Evans, J Morgan.
Dragons: L Morgan; R Jones, J Dixon, H Amos, B Kent; E Davies, G Davies; B Edwards, D Rossiter, D Goode, S Andrews, A Smith, K Pyart, G Eldred, J Benjamin (capt). Replacements: E Dee, T Shipp, D Jones, W Oliver, J Evans, N Martin, M Sevenoaks