The final of the LV= Cup will be played at Sixways, home of Guinness Premiership club Worcester Warriors, on Sunday, March 21.
The culmination of the Anglo-Welsh tournament will kick off at 3.30pm and be broadcast live by Sky Sports.
Cardiff Blues, Gloucester Rugby, Northampton Saints and Saracens are all in the hunt for silverware, which offers a Heineken Cup place to an English winner.
LV= Cup Tournament Director Terry Burwell said: "Sixways is a first class stadium with excellent facilities and we are delighted to take the LV= Cup final there as the RFU has done with some of England's Under 20 fixtures.
"All four semi finalists have fervent support and we believe that March 21 will be a great day out for whichever two clubs get there. The LV= Cup has given us some spectacular rugby this season, as well as the chance to see some exciting young English players, and with the semi-finals just a week earlier there will be a great momentum towards the final."
Worcester Warriors General Manager Charlie Little added: "It is a great honour and huge privilege for Worcester Warriors to be chosen to host the LV=Cup final in 2010.
"This is recognition for the recent development of Sixways Stadium and our facilities as we have strived to create what we believe is one of the best rugby venues in the country. That effort and vision has previously seen us host England representative matches and we are now delighted to be able to host a major domestic cup final for the first time in our history.
"We would like to wish the best of luck to all the semi-finalists and look forward to welcoming the teams and supporters for a memorable LV=Cup final in March."
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).