Kenfig Hill, also doing well in Three south-west, welcome Gilfach Goch, 19-0 victors of Llandaff North on Tuesday evening for a place in the quarter-finals.
Division Three south-east table toppers Penarth have taken their league form into the cup and are only one step away from the last eight after beating Aberdare 17-13.
They face either Rhydyfelin or Penallta while Aberystwyth host Crymych or Laugharne after dismantling Division Three West leaders Newcastle Emlyn 23-0.
Loughor earned a home draw against Cwmavon or Aberavon Quins while Gwernyfed await the winner between Mumbles and Waunarlwydd.
Brynmawr or Tredegar Ironsides have home advantage against North Wales opponents Nant Conwy or Caernarvon while Ruthin and Denbigh will also head south to face either Llantwit Fardre or Pentyrch.
SWALEC PLATE 2009-2010
To be played the weekend of 20th February 2010
Loughor v Cwmavon /Aberavon Quins
Llantwit Fardre /Pentyrch v Ruthin /Denbigh
Treorchy /Maesteg v Skewen
Gwernyfed v Mumbles/Waunarlwydd
Rhydyfelin /Penallta v Penarth
Brynmawr Tredegar Ironsides v Nant Conwy RFC/Caernarvon RFC
Kenfig Hill v Gilfach Goch
Aberystwyth v Crymych/Laugharne