Skewen's reward for a hard-fought 3-0 over local rivals Glynneath is a trip to either Treorchy or Maesteg in Round Four of the Swalec Plate.
The runaway leaders in Division Three South-West face an early test of their Division Two credentials against either of the fallen giants who are both riding high in that league.
Kenfig Hill, also doing well in Three south-west, welcome Gilfach Goch, 19-0 victors of Llandaff North on Tuesday evening for a place in the quarter-finals.
Division Three south-east table toppers Penarth have taken their league form into the cup and are only one step away from the last eight after beating Aberdare 17-13.
They face either Rhydyfelin or Penallta while Aberystwyth host Crymych or Laugharne after dismantling Division Three West leaders Newcastle Emlyn 23-0.
Loughor earned a home draw against Cwmavon or Aberavon Quins while Gwernyfed await the winner between Mumbles and Waunarlwydd.
Brynmawr or Tredegar Ironsides have home advantage against North Wales opponents Nant Conwy or Caernarvon while Ruthin and Denbigh will also head south to face either Llantwit Fardre or Pentyrch.
SWALEC PLATE 2009-2010
ROUND 4 To be played the weekend of 20th February 2010
Loughor v Cwmavon /Aberavon Quins
Llantwit Fardre /Pentyrch v Ruthin /Denbigh
Treorchy /Maesteg v Skewen
Gwernyfed v Mumbles/Waunarlwydd
Rhydyfelin /Penallta v Penarth
Brynmawr Tredegar Ironsides v Nant Conwy RFC/Caernarvon RFC
Kenfig Hill v Gilfach Goch
Aberystwyth v Crymych/Laugharne
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s