Division Six south-east leaders Hafodyrynys have been handed the toughest possible rout to the quarter-finals of the Swalec Bowl after being handed an away tie at Pyle.
Hafodyrynys have only lost one game all season but must first get past Risca before facing Pyle who currently top Division Four south-west and brushed past Glyncorrwg 46-5 in the last round.
Bethesda are the only north Wales team guaranteed their place in Round Five after defeating Machynlleth and welcome either Bettws or New Tredegar.
Amman United await Pontarddulais or Trebanos while Birchgrove's 28-0 win over Cwmgwrach earned them a home tie against Llangodog or Milford Haven.
Cardiff rivals Llanrumney and Cardiff University will fight for a place at Bridgend Sports or Porth while Talywain take on either Abercarn or Abertillery if they defeat Blaenavon.
The top two teams from Division Six central, Cambrian Welfare and Glyncoch, compete for a trip to either Pontardawe or Bryncethin. Division Four east's Monmouth will fancy their chances against lower-league St Joseph and Senghenydd, if they overcome a tricky trip north to Bala.
To be played the weekend of 20th February 2010
Bala /Monmouth v Senghenydd RFC/St Joseph RFC
Pontardawe /Bryncethin v Cambrian Welfare RFC/Glyncoh
Pyle Hafodyrynys /Risca
Bridgend Sports /Porth v Llanrumney RFC/ Cardiff Uni RFC
Talywain /Blaenavon v Abercarn RFC/Abertillery BG
Bethesda v Bettws RFC/New Tredegar
Amman United v Pontarddulais RFC/Trebanos
Birchgrove v Llangadog RFC/Milford Haven
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s