Aaron Bramwell returns to the Ponty starting line-up after being on Wales Sevens duty.
Pontypridd resume their league campaign with a home game against Ebbw Vale at Sardis Road this evening (KO 7:15pm).
With a top four finish in the Premiership the target, Ponty will need to harvest valuable points against the club rooted at the bottom of the table.
Ebbw Vale in turn will be battling for survival in their relegation dogfight with Pontypool, all in all making for an intriguing must win encounter for both contestants.
As the games come thick and fast in league and cup, Pontypridd take an opportunity to rest some players and to utilise the strength in depth of their squad.
Gary Williams slots in at full back, behind a new centre pairing of Adam Thomas and Dafydd Lockyer. A revised front row union of Jon Williams, Tom Hetherington and Ryan Harford will take the field, with Darren Waters coming in on the open-side flank. Aaron Bramwell returns from Wales Sevens duties to take a place on the bench.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series