Italy have made four changes plus one positional switch for Saturday's RBS Six Nations match against Wales at the Millennium Stadium, Cardiff.
They bring in wing Kaine Robertson, scrum-half Pablo Canavosio, lock Carlo Del Fava and flanker Paul Derbyshire while Andrea Masi switches from wing to centre.
But both Del Fava and Derbyshire will be subject to late fitness checks after the forward duo picked up muscle injuries in pre-match training.
The pair impressed coach Nick Mallett after coming on as second-half substitutes in last week's 46-20 defeat in France, contributing to a late rally in which Del Fava scored a try.
If they are not fit, second-row Marco Bortolami and back-rower Josh Sole will return to the starting side and Valerio Bernabo and Manoa Vosawai will come onto the bench.
Canavosio was chosen at scrum-half after coming on for the untidy Tito Tebaldi in Paris and scoring a late try. Robertson was recalled after starting the Azzurri's opening 29-11 defeat in Ireland. Gonzalo Canale drops to the bench with Masi switched to outside centre.
Mallett had stuck with the same side for the previous three games, against France, Scotland and a 17-12 defeat by England.
Wales and Italy both go into match with two points gained from wins over Scotland and the loser could finish last if the Scots, who drew 15-15 with England last weekend, beat Ireland in Dublin.
Italian key play maker Craig Gower is expecting Wales to come out hard from the outset. "They will come out firing and it will be a big challenge for us," he said.
"We have to do the basics right and see what comes. We are using the ball more than we used to. Ireland was a disappointing game for us in terms of moving the ball but we improved against England and Scotland and will be looking to create opportunities."
He added: "We have changed from being a forward-based team; I do not want to give the ball away all the time but you have to be smart about the way you play and my job is to make it work, getting us in the right positions and playing a little bit. We are building as a team and we want to start getting results away from Rome."
Italy: L McLean (Treviso); K Robertson (Viadana), A Masi (Racing-Metro), G Garcia (Treviso), Mirco Bergamasco (Stade Francais); C Gower (Bayonne), P Canavosio (Viadana); S Perugini (Bayonne), L Ghiraldini (Treviso), M Castrogiovanni (Leicester), C Del Fava (Viadana)/M Bortolami (Gloucester), Q Geldenhuys (Viadana), P Derbyshire (Padova)/J Sole (Viadana), Mauro Bergamasco (Stade Francais), A Zanni (Treviso).
Replacements: F Ongaro (Saracens), M Aguero (Saracens), M Bortolami (Gloucester)/V Bernabo (Roma), J Sole (Viadana)/M Vosawai (Parma), T Tebaldi (Gran Parma), R Bocchino (Rovigo), G Canale (Clermont Auvergne).
Wales Under 18 captain Callum Bradbury is delighted to have seen his side claim a narrow 18-17 victory against a strong SA Schools 'A' side to end the three-match Under 19 International Series in South Africa on a high note.
The Wales U18 squad spent an emotional day in the drug-riddled townnship of Hout Bay. Hout Bay Warriors President Fred Johannes said the visit was 'the talk of the town' and will dream about the day everyday for the rest of his life.
RGC 1404's new head coach Mark Jones is hoping to build 'something special' in north Wales and is already looking forward to the development region participating in the Principality Premiership for the very first time.
A joint venture between the WRU and Admiral saw hundreds of children enjoy the Admiral Festival of Rugby held at the National Centre of Excellence at the weekend where Welsh internationals Sam Warburton, Scott Williams and Rob Evans were in attendance.
Wll Jones leads Wales U18s into battle this afternoon against Italy where the Welsh side will be seeking to bounce back from their narrow defeat to SA Schools in their opening clash of the U19 International Series
All four regions attended a successful training camp staged last weekend at the WRU National Centre of Excellence. It was a chance for new Wales Women's head coach Rowland Phillips to deliver his key messages to players and coaches as he prepares for the new season.
Wales U18 Team Manager Gethin Watts believes the next couple of weeks will be 'extremely beneficial' to the future of Welsh rugby as his side prepare to take part in the Under 19 International Series being staged in South Africa.
The WRU is searching for 12 new rugby development apprentices following a successful first year of its WRU Coach Core programme. Craig Duncan and Jess Hancock have flourished in the first year of the programme which has given them a real direction in their lives.
The WRU signed TV comedian Rhod Gilbert up to a 'Coaching Children Level 1' course before letting him loose on an U8s side at Whitland Junior Borderers - we went behind the scenes to film the making of 'Rhod Gilbert's Work Experience' see the results here.
Llandovery are aiming to make it three titles in a row in this year's Foster's National 7s being held at BT Sport Cardiff Arms Park on Sunday 28 August. Drovers assistant coach Simon Davies and Lee Rees assess their sides chances
A pioneering strength and conditioning programme has been delivered to more than 8000 boys and girls at hub schools throughout Wales this season, helping to develop stronger, more flexible athletes for rugby and other sports.
The Singha Premiership Rugby 7s Series returns to the BT Sport Cardiff Arms Park on July 22nd when all four Welsh regions go head to head. Scarlets skills coach Dai Flanagan and Blues Elite Performance Pathway Manager Richard Hodges along with current Welsh squad members were at the launch of this season's event