Italy have made four changes plus one positional switch for Saturday's RBS Six Nations match against Wales at the Millennium Stadium, Cardiff.
They bring in wing Kaine Robertson, scrum-half Pablo Canavosio, lock Carlo Del Fava and flanker Paul Derbyshire while Andrea Masi switches from wing to centre.
But both Del Fava and Derbyshire will be subject to late fitness checks after the forward duo picked up muscle injuries in pre-match training.
The pair impressed coach Nick Mallett after coming on as second-half substitutes in last week's 46-20 defeat in France, contributing to a late rally in which Del Fava scored a try.
If they are not fit, second-row Marco Bortolami and back-rower Josh Sole will return to the starting side and Valerio Bernabo and Manoa Vosawai will come onto the bench.
Canavosio was chosen at scrum-half after coming on for the untidy Tito Tebaldi in Paris and scoring a late try. Robertson was recalled after starting the Azzurri's opening 29-11 defeat in Ireland. Gonzalo Canale drops to the bench with Masi switched to outside centre.
Mallett had stuck with the same side for the previous three games, against France, Scotland and a 17-12 defeat by England.
Wales and Italy both go into match with two points gained from wins over Scotland and the loser could finish last if the Scots, who drew 15-15 with England last weekend, beat Ireland in Dublin.
Italian key play maker Craig Gower is expecting Wales to come out hard from the outset. "They will come out firing and it will be a big challenge for us," he said.
"We have to do the basics right and see what comes. We are using the ball more than we used to. Ireland was a disappointing game for us in terms of moving the ball but we improved against England and Scotland and will be looking to create opportunities."
He added: "We have changed from being a forward-based team; I do not want to give the ball away all the time but you have to be smart about the way you play and my job is to make it work, getting us in the right positions and playing a little bit. We are building as a team and we want to start getting results away from Rome."
Italy: L McLean (Treviso); K Robertson (Viadana), A Masi (Racing-Metro), G Garcia (Treviso), Mirco Bergamasco (Stade Francais); C Gower (Bayonne), P Canavosio (Viadana); S Perugini (Bayonne), L Ghiraldini (Treviso), M Castrogiovanni (Leicester), C Del Fava (Viadana)/M Bortolami (Gloucester), Q Geldenhuys (Viadana), P Derbyshire (Padova)/J Sole (Viadana), Mauro Bergamasco (Stade Francais), A Zanni (Treviso).
Replacements: F Ongaro (Saracens), M Aguero (Saracens), M Bortolami (Gloucester)/V Bernabo (Roma), J Sole (Viadana)/M Vosawai (Parma), T Tebaldi (Gran Parma), R Bocchino (Rovigo), G Canale (Clermont Auvergne).
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).
The winners of a filmmaking competition organised by the education charity Into Film and the WRU enjoyed a behind the scenes tour of the Millennium Stadium - and a chance to be photographed with the WRU's fire-breathing, rugby loving mascot, Scorch The Dragon, and Welsh international, Jake Ball.