Italy have made four changes plus one positional switch for Saturday's RBS Six Nations match against Wales at the Millennium Stadium, Cardiff.
They bring in wing Kaine Robertson, scrum-half Pablo Canavosio, lock Carlo Del Fava and flanker Paul Derbyshire while Andrea Masi switches from wing to centre.
But both Del Fava and Derbyshire will be subject to late fitness checks after the forward duo picked up muscle injuries in pre-match training.
The pair impressed coach Nick Mallett after coming on as second-half substitutes in last week's 46-20 defeat in France, contributing to a late rally in which Del Fava scored a try.
If they are not fit, second-row Marco Bortolami and back-rower Josh Sole will return to the starting side and Valerio Bernabo and Manoa Vosawai will come onto the bench.
Canavosio was chosen at scrum-half after coming on for the untidy Tito Tebaldi in Paris and scoring a late try. Robertson was recalled after starting the Azzurri's opening 29-11 defeat in Ireland. Gonzalo Canale drops to the bench with Masi switched to outside centre.
Mallett had stuck with the same side for the previous three games, against France, Scotland and a 17-12 defeat by England.
Wales and Italy both go into match with two points gained from wins over Scotland and the loser could finish last if the Scots, who drew 15-15 with England last weekend, beat Ireland in Dublin.
Italian key play maker Craig Gower is expecting Wales to come out hard from the outset. "They will come out firing and it will be a big challenge for us," he said.
"We have to do the basics right and see what comes. We are using the ball more than we used to. Ireland was a disappointing game for us in terms of moving the ball but we improved against England and Scotland and will be looking to create opportunities."
He added: "We have changed from being a forward-based team; I do not want to give the ball away all the time but you have to be smart about the way you play and my job is to make it work, getting us in the right positions and playing a little bit. We are building as a team and we want to start getting results away from Rome."
Italy: L McLean (Treviso); K Robertson (Viadana), A Masi (Racing-Metro), G Garcia (Treviso), Mirco Bergamasco (Stade Francais); C Gower (Bayonne), P Canavosio (Viadana); S Perugini (Bayonne), L Ghiraldini (Treviso), M Castrogiovanni (Leicester), C Del Fava (Viadana)/M Bortolami (Gloucester), Q Geldenhuys (Viadana), P Derbyshire (Padova)/J Sole (Viadana), Mauro Bergamasco (Stade Francais), A Zanni (Treviso).
Replacements: F Ongaro (Saracens), M Aguero (Saracens), M Bortolami (Gloucester)/V Bernabo (Roma), J Sole (Viadana)/M Vosawai (Parma), T Tebaldi (Gran Parma), R Bocchino (Rovigo), G Canale (Clermont Auvergne).
The WRU has teamed up with Crawshay's to tour Georgia in June. The side, which will be called the Crawshays WRU President's XV, will play Emerging Georgia twice, in a tour which supports the Welsh Government's efforts to grow relations between the two countries.
Wales Sevens are looking to re-group after a disappointing tournament last time out in South Africa. The next double leg in New Zealand and Las Vegas offers Gareth Williams a chance to redeem themselves.
Wales Women's head coach Rhys Edwards was at Llandovery to see the conclusion of an entertaining Women's Regional championship where any one of three teams were in contention for title glory on the last day of action.
Christmas has come early at Glynneath rugby club, one of a number around Wales who have received an array of merchandise and equipment this December courtesy of the Welsh Rugby Union's £750,000 participation points scheme.
The WRU have been delivering on the scheme - which gives individual clubs access to up to £5,000 worth of supplies and equipment each for the 2014/2015 season - over the last two weeks and today (Friday) were received by a special guest in Glynneath, club president and pitch marker Max Boyce.