Dan Lydiate will lead a Wales side that includes four personnel changes for the clash against Italy on Saturday (KO 14:30).
We are disappointed with last week, especially the first half but a win on Saturday will see us finish the tournament in second and we have to aim for that now
Luke Charteris, Justin Tipuric, Rhys Webb and Hallam Amos all come into the starting XV for Wales' final 2016 RBS 6 Nations encounter. Amongst the replacements Gethin Jenkins returns to the match day squad along with Jake Ball and Ross Moriarty.
Lydiate, who previously captained Wales in a midweek tour match against EP Kings in 2014, leads Wales for the first time in a Test match and is joined in the back row by Ospreys teammate Tipuric and No8 Taulupe Faletau.
Tipuric replaces Sam Warburton who suffered concussion against England and has been given more time to recover.
In the second row, the combination that finished the game at Twickenham, Bradley Davies and Luke Charteris, pack down together again. Charteris comes in for Alun Wyn Jones who misses out due to a heel injury.
Front-row trio Rob Evans, Scott Baldwin and Samson Lee pack down for a fifth consecutive Six Nations match together.
In the backline Webb, whose last start was against Italy in September 2015, wears the nine jersey alongside Dan Biggar at 10. It is an unchanged midfield with Jamie Roberts partnering Jonathan Davies.
The tournaments joint top try scorer, George North, switches to wear 14, with Amos coming in at 11 due to a foot injury to Alex Cuthbert. Liam Williams continues at full-back.
"This weekend it is all about finishing off the tournament well and putting in a big performance," said Wales Head Coach Warren Gatland.
"We are disappointed with last week, especially the first half but a win on Saturday will see us finish the tournament in second and we have to aim for that now.
"There are a number of changes, a couple injury enforced. Alun Wyn Jones has a foot problem that we have been managing for a while and he has played a lot of games. We have given Sam Warburton the week off, we decided not to push him through all the return to play protocols and we have also been managing a heel injury with Alex (Cuthbert) so Hallam comes onto the left wing.
"It's good to see Rhys (Webb) back and starting, it's a good opportunity for him. Saturday is a good chance for some of the players to redeem themselves and we are looking for a big performance.
"I've been involved in a couple of times when Dan (Lydiate) has captained the midweek sides and he jumped at the opportunity this weekend and it will be good to see how he goes."
Ken Owens, Gethin Jenkins and Aaron Jarvis are named as the front row replacements. Jake Ball and Ross Moriarty complete the forward contingent. Gareth Davies, Rhys Priestland and Gareth Anscombe provide the backline cover.
Wales team to play Italy:
Liam Williams (Scarlets), George North (Northampton Saints), Jonathan Davies (ASM Clermont), Jamie Roberts (Harlequins), Hallam Amos (Newport Gwent Dragons), Dan Biggar (Ospreys), Rhys Webb (Ospreys); Rob Evans (Scarlets), Scott Baldwin (Ospreys), Samson Lee (Scarlets), Bradley Davies (Wasps), Luke Charteris (Racing 92), Dan Lydiate (Ospreys, Capt), Justin Tipuric (Ospreys), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Ken Owens (Scarlets), Gethin Jenkins (Cardiff Blues), Aaron Jarvis (Ospreys), Jake Ball (Scarlets), Ross Moriarty (Gloucester Rugby), Gareth Davies (Scarlets), Rhys Priestland (Bath Rugby), Gareth Anscombe (Cardiff Blues).
Principality Stadium will host the UEFA Champions League Final in six weeks' time. WRU chairman Gareth Davies, Football Association of Wales chief executive Jonathan Ford and Ambassador Ian Rush joined young sports fans at the trophy arrival at the venue to celebrate the magnitude of the event on Saturday 3rd June (kick-off 19.45).
British and Irish Lions captain Sam Warburton is looking forward to bringing together players from Ireland, Scotland, England and Wales for the biggest challenge of their careers - a series against world champions, New Zealand.
For the fifth year running, Wales referee Nigel Owens will be in charge of proceedings at Judgement Day V at Principality Stadium. It promises to be 'extra special' for the Wales' favourite ref, as he will be making his 150th appearance in the league.
There will be no shortage of inside knowledge from Bowl Finalists Caerphilly and Amman United when they face each other on Sunday at National Finals Day. Caerphilly hooker Rhys Cleverly knows the Principality Stadium pitch better than most as a matchday groundsman, while Amman United can look to Wales' record try scorer Shane Williams for some helpful advice.
Two hundred and 40 teams competed in the inaugural Urdd WRU 7s held at Pencoed last week with Welsh internationals Steff Andrews and Jasmine Joyce impressed with the talent on display, as was Urdd chief executive, Sioned Hughes.
The countdown is on for Judgement Day V as tickets for the big day at Principality Stadium soar through the 50,000 mark. Players and coaches alike are bursting at the seams to play in the double header with Dragons coach Kingsley Jones claiming there is a 'real buzz' about the event.
WRU TV went behind the scenes when the four regions got together to test their skill set for the BBC's Scrum V Live rugby show, at the WRU National Centre of Excellene in the build up to Judgement Day V. Blues' Matthew Morgan was one of the stars of the show while the Dragons' Cory Hill proved a surprise package...the full set of results will be revealed on tv screens on matchday
Wales assistant coach Richie Pugh is confident his side can cause a few headaches in the Hong Kong Sevens this weekend. In a tough group, Wales kick off their campaign against New Zealand on Friday before playing Japan and Fiji, who are chasing their third consecutive Hong Kong title, on Saturday.
Bedwas had to overcome a stubborn Carmarthen Quins side before winning the Foster's Challenge Cup final in Bridgend with a 23-18 victory. Bedwas captain Nicky Griffiths pays tribute to his side who have claimed the club's first piece of silverware in the modern era.
Team coach Brett Davey is aiming to keep his unbeaten run in cup finals at Principality Stadium intact when his side take on Amman United in the WRU Bowl final, after he guided Caerphilly to a 20-14 win against Cilfynydd in the semi-finals.
Penallta are hoping to go one step further than last season when falling to Bedlinog in the WRU Plate Final. After a titanic struggle against Nant Conwy, they have given themselves a great chance, after a hard fought 18-13 semi-final victory.