Dan Lydiate will lead a Wales side that includes four personnel changes for the clash against Italy on Saturday (KO 14:30).
We are disappointed with last week, especially the first half but a win on Saturday will see us finish the tournament in second and we have to aim for that now
Luke Charteris, Justin Tipuric, Rhys Webb and Hallam Amos all come into the starting XV for Wales' final 2016 RBS 6 Nations encounter. Amongst the replacements Gethin Jenkins returns to the match day squad along with Jake Ball and Ross Moriarty.
Lydiate, who previously captained Wales in a midweek tour match against EP Kings in 2014, leads Wales for the first time in a Test match and is joined in the back row by Ospreys teammate Tipuric and No8 Taulupe Faletau.
Tipuric replaces Sam Warburton who suffered concussion against England and has been given more time to recover.
In the second row, the combination that finished the game at Twickenham, Bradley Davies and Luke Charteris, pack down together again. Charteris comes in for Alun Wyn Jones who misses out due to a heel injury.
Front-row trio Rob Evans, Scott Baldwin and Samson Lee pack down for a fifth consecutive Six Nations match together.
In the backline Webb, whose last start was against Italy in September 2015, wears the nine jersey alongside Dan Biggar at 10. It is an unchanged midfield with Jamie Roberts partnering Jonathan Davies.
The tournaments joint top try scorer, George North, switches to wear 14, with Amos coming in at 11 due to a foot injury to Alex Cuthbert. Liam Williams continues at full-back.
"This weekend it is all about finishing off the tournament well and putting in a big performance," said Wales Head Coach Warren Gatland.
"We are disappointed with last week, especially the first half but a win on Saturday will see us finish the tournament in second and we have to aim for that now.
"There are a number of changes, a couple injury enforced. Alun Wyn Jones has a foot problem that we have been managing for a while and he has played a lot of games. We have given Sam Warburton the week off, we decided not to push him through all the return to play protocols and we have also been managing a heel injury with Alex (Cuthbert) so Hallam comes onto the left wing.
"It's good to see Rhys (Webb) back and starting, it's a good opportunity for him. Saturday is a good chance for some of the players to redeem themselves and we are looking for a big performance.
"I've been involved in a couple of times when Dan (Lydiate) has captained the midweek sides and he jumped at the opportunity this weekend and it will be good to see how he goes."
Ken Owens, Gethin Jenkins and Aaron Jarvis are named as the front row replacements. Jake Ball and Ross Moriarty complete the forward contingent. Gareth Davies, Rhys Priestland and Gareth Anscombe provide the backline cover.
Wales team to play Italy:
Liam Williams (Scarlets), George North (Northampton Saints), Jonathan Davies (ASM Clermont), Jamie Roberts (Harlequins), Hallam Amos (Newport Gwent Dragons), Dan Biggar (Ospreys), Rhys Webb (Ospreys); Rob Evans (Scarlets), Scott Baldwin (Ospreys), Samson Lee (Scarlets), Bradley Davies (Wasps), Luke Charteris (Racing 92), Dan Lydiate (Ospreys, Capt), Justin Tipuric (Ospreys), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Ken Owens (Scarlets), Gethin Jenkins (Cardiff Blues), Aaron Jarvis (Ospreys), Jake Ball (Scarlets), Ross Moriarty (Gloucester Rugby), Gareth Davies (Scarlets), Rhys Priestland (Bath Rugby), Gareth Anscombe (Cardiff Blues).
Head coach Rowland Phillips and key front rower Carys Phillips look ahead to games against Spain and Ireland as Wales Women ramp up their preparations for the forthcoming Six Nations. The two warm-up games are a 'massive opportunity to refine the squad' according to the Welsh camp.
Martyn Phillips has discussed details of the newly published 'Strategy for Welsh Rugby' which puts in black and white terms the plans and direction of the governing body of the national sport in Wales for the next decade.
WRU chief executive Martyn Phillips has urged Welsh rugby fans to follow in the footsteps of their soccer counterparts at last summer's Euro Championship by backing their team to the hilt in the upcoming RBS 6 Nations campaign.
Chief executive Martyn Phillips has highlighted the plans for Wales to become a breeding ground for national and elite club rugby coaches, which are contained in the WRU's 10-year 'Strategy for Welsh Rugby'.
Andrew Coombs is enjoying his new role as Nelson forwards coach. The former Dragons and Wales lock has big ambitions to become a professional coach but feels it's important to learn the ropes in grassroots rugby and where better than his home club Nelson, with friends and family close to hand.
Students at Brynllywarch Hall School, near Newtown, have transformed their own lives, and are now having a positive impact on others through rugby. The sport has had a life-changing effect on the well-being of the students who are now delivering rugby sessions to local primary schools and playing for a new mixed ability side
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.