Jean De Villiers is out of action for eight weeks.
The Springboks will be without skipper Jean de Villiers for the two Test Castle Lager Series against Wales next month.
The Stormers centre underwent surgery on a knee injury last weekend and will be out of action for eight weeks. He hopes to return for the start of Rugby Championship in August.
"Losing our captain is a massive setback," said Springbok coach Heyneke Meyer. "Jean has been superb as our leader on and off the field and he was in excellent form as well.
"He is a wonderful ambassador for South Africa and is respected across the world as a leader - we will certainly miss him next month. His injury is the latest in a string of setbacks we've experienced, and with Jaque Fourie also ruled out it means we'll play with a new captain and a new midfield combination next month.
"Luckily we have good depth in the squad at centre, but replacing your captain is always difficult. We have a number of good leaders in the squad, but I don't want to rush a decision on the captaincy as we still have to finalise the squad for June."
De Villiers' place in the training squad that gathered in Durban on Sunday has been taken by promising Sharks lock Stephan Lewies. The Springboks will face a World XV at Newlands before they tackle Wales on successive weekends.
"It's great to see the excitement on the faces of the players, not only the uncapped guys, but also experienced Springboks," said Meyer.
"Everyone knows this is a very important season and with 18 matches left until we depart for the Rugby World Cup, the players are keen to impress and fight for positions in the squad. Our focus for now, however, is on the World XV match and ensuring we start the season on a positive note."
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).