In the forwards, Tom Bristow, Nathan Vella and Peter Edwards make up an all changed front row, replacing Alec Hepburn, Nathan Morris and Paddy Ryan.
In the back row, Richard Thorpe comes in at blindside flanker for Mitch Lees, while Carl Kirwan replaces USA Eagles flanker John Quill, who moves to the bench.
When the two sides met that the Kassam in November, Welsh came out on top 22-7 thanks to tries from Alex Davies, Seb Stegmann and Ollie Stedman.
However, while Welsh's 45-7 win over Jersey at the Kassam last Saturday was their seventh straight Championship win, Bristol's 33-24 victory at Moseley took their winning run in the league to 11 games.
The last time the Exiles visited the Memorial Ground was in March 2012, when a last-gasp Matthew Jones penalty saw Bristol snatch a 12-12 draw.
London Welsh: 15. Toby L'Estrange*, 14. Seb Stegmann, 13. Tom May* (C), 12. Hudson Tonga'uiha*, 11. Joe Ajuwa, 10. Alex Davies, 9. Tyson Keats, 1. Tom Bristow, 2. Nathan Vella, 3. Peter Edwards, 4. Matt Corker, 5. Will Spencer, 6. Richard Thorpe, 7. Carl Kirwan, 8. Daniel Browne.