And this year's grudge match promises to be the most exciting yet as reigning champions Swansea, bolstered Wales Sevens star Will Thomas, go for a third victory over their Cardiff rivals at the Millennium Stadium.
Wales U20 captain Steff Hughes and fellow squad members Connor Lloyd and Nicky Thomas were all involved in Swansea University's victory last season with Thomas returning for tonight's crunch match.
Former Wales international and Swansea University 1st XV member Paul Thorburn last season swapped his green and white colours for a neutral position as Chairman of Welsh Varsity.
He is expecting this season's Millennium Stadium extravaganza to attract more welsh rugby fans as well as the students and alumni that flock to the event year on year.
"The Varsity match between Wales' two great rugby institutions has developed into a must-see occasion which now attracts close to 20,000 spectators. It's one for all rugby lovers, not only because of the carnival atmosphere, but also because of the style and manner in which the game is played."
Cardiff University: Iwan Phillips, Tom O'Flaherty, Jack Watters, Arthur Ellis, James Brock, Jack Neville, John Preddy, James Thomas (Capt), George Lee, James Sawyer, Ben Egan, Ollie Green, Aled Rees, Joe Franchi, Tom Boot
Replacements: Morgan Bozariko, Aled Rees, Dan Mock, begin Unwin, Dave Wayman, Bryn Phillips, Dan Brownlee, Ben Madgwick, Andy Evans.
Swansea University: Eliott Jones, Andrew Claypole, Josh Bartlett, Mathew Jenkins, Hugo Jafari, Will Thomas, Josh Guy; Saman Razapour, Tom Bull, Nicky Thomas, Rory Thornton, Jon Barkley, Reuben Tucker (Capt), Jack Perkins, Adam Scanlon.
Replacements: Rhodri Clancy, Tom Kaijaks, Sean McDonald-Roberts, Josh Walker, Arun Thompson, Shaun Clarke, Jack Shields, Ashley Evans, David Evans, Jedd Evans.
You can view the game from either of the links below, just prior to kick-off: