Ospreys' Dan Biggar makes his first start of the tournament at fly-half.
Wales have made six changes to their starting line-up for the RBS 6 Nations clash against Scotland at the Millennium Stadium on Saturday (KO 2.45pm).
Saturday is an opportunity for us to put in a performance we know we can and finish the Six Nations on a high
Three come in the backline with Liam Williams (Scarlets) and Mike Phillips (Racing Metro) in for injured duo Leigh Halfpenny and Rhys Webb, at full-back and scrum-half respectively.
Dan Biggar makes his first start of the tournament at fly-half, partnering Phillips at half-back.
The rest of the backs remain unchanged from Sunday's game at Twickenham with Jamie Roberts (Racing Metro) and Jonathan Davies (Scarlets) named in the centre and Alex Cuthbert (Cardiff Blues) and George North (Northampton Saints) on the wings.
In the pack Gethin Jenkins (Cardiff Blues) will become Wales' most-capped player when he makes his 105th appearance on Saturday, moving one ahead of Stephen Jones.
Jenkins will feature in a new look front-row alongside Scarlets pair Ken Owens and Rhodri Jones who get their first starts of the campaign.
In the second-row Luke Charteris (Perpignan) returns from injury to take his place alongside Alun Wyn Jones (Ospreys).
The back-row remains unchanged with captain Sam Warburton (Cardiff Blues) playing alongside Dan Lydiate (Racing Metro) and Taulupe Faletau (Newport Gwent Dragons).
Wales will be intent on finishing the competition on a high against a Scotland team who are looking for their first victory in Cardiff since 2002.
"Saturday is an opportunity for us to put in a performance we know we can and finish the Six Nations on a high," said Gatland.
"We've made a number of changes and freshened things up with a just a six day turnaround between matches.
"Liam (Williams) and Mike (Phillips) come in with Leigh (Halfpenny) and Rhys (Webb) ruled out and Dan Biggar gets his opportunity at fly-half.
"In the front-row Ken Owens and Rhodri Jones get their chance to start after impressing off the bench and it's good to have Luke (Charteris) back from injury in the second-row.
"Scotland will come looking to play some rugby and had a morale boosting win against Italy and were unlucky to lose against France in recent weeks.
"We will be looking for a more accurate execution this week to finish with a win at home in Cardiff."
Ospreys duo Richard Hibbard and Adam Jones drop to the bench and are named alongside Paul James (Bath Rugby), Jake Ball (Scarlets) and Justin Tipuric (Ospreys) as the forward replacements. Scarlets half-backs Rhodri Williams and Rhys Priestland are joined by Perpignan's James Hook as backs cover.
WALES SQUAD TO PLAY SCOTLAND:
Liam Williams (Scarlets), Alex Cuthbert (Cardiff Blues), Jonathan Davies (Scarlets), Jamie Roberts (Racing Metro), George North (Northampton Saints), Dan Biggar (Ospreys), Mike Phillips (Racing Metro), Gethin Jenkins (Cardiff Blues), Ken Owens (Scarlets), Rhodri Jones (Scarlets), Luke Charteris (Perpignan), Alun Wyn Jones (Ospreys), Dan Lydiate (Racing Metro), Sam Warburton (CAPT - Cardiff Blues), Taulupe Faletau (Newport Gwent Dragons).
Replacements: Richard Hibbard (Ospreys), Paul James (Bath Rugby), Adam Jones (Ospreys), Jake Ball (Scarlets), Justin Tipuric (Ospreys), Rhodri Williams (Scarlets), Rhys Priestland (Scarlets), James Hook (Perpignan).
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.