As it happens, both teams are right in the mix and with no margin for error, the stakes have rarely been higher.
After a resounding win over France, the Welsh might have wished to go straight into this match, but a week's break provides opportunity for bruises to heal and aches to go away ahead of what is undoubtedly going to be a very physical encounter.
Wales are looking for their fourth win in a row over the Sweet Chariot and Paddy Power, official betting partner of the Wales Rugby Union, give the visitors a decent chance of pulling it off. Wales are 7/4 to win the match and 10/11 to win with a +5 handicap.
There's no getting away from the fact that first half of the naughties was a bleak time for Wales in the relationship with the old enemy, but second half of the decade saw a turnaround that has largely carried on right up to now. Wales have won six of their last nine 6 Nations matches against England that ratio is perfectly maintained when looking solely at 6 Nations games at Twickenham, courtesy of two wins from their last three visits.
Interesting, those two wins in Twickenham came by seven point margins. If you fancy three of a kind, you can back Wales to win by exactly seven points at 30/1, but most punters will want a little more leeway. It's 15/2 that Wales win by 6-10 points on Sunday and in what's likely to be a close affair, the option of taking Wales to win by 1-5 points at 5/1 is also worthy of consideration.
With Cuthbert, North and Halfpenny in the starting XV, Wales have a number of players who have touched down against England, but it's Cuthbert who stands out as the main threat. He was a thorn in the side of the Red Rose last year thanks to two tries and he'll once again be a major weapon for Wales in London. He's 9/1 to be First Tryscorer on Sunday and 8/1 to repeat last year's feat of scoring two tries in the game. Jonathan Davies is in line for his first start in a Wales jersey since November's Test against South Africa and he's 9/2 to mark that return by scoring a try in the match.
As you might expect with a rivalry against your oldest rivals, tempers have flared over the years. In fact, over the last 12 meetings of the teams, there's been 13 yellow cards handed out. There were none shown the most recent clash last March which makes the odds of 8/13 for a Yellow Card to be shown this time around well worth a look.
Perhaps because there often hasn't been a lot to choose between the two teams, drop goals have also featured relatively frequently over the last few years. There's been seven scored over the last 10 matches and at that level of regularity, 9/4 for a Drop Goal to be scored looks like value.