Heyneke Meyer's men also face Scotland and France this month but de Villiers insists all eyes are on their mammoth Millennium Stadium clash as they look to make it 14 straight wins over Wales.
"We're all very excited to be here and we are looking forward to the challenge of playing three very tough Test matches on this tour," he said.
"At this stage, we're not looking past the Wales Test, which promises to be an epic match.
"We had three hard days of training in Johannesburg before we left, but the weather was warm and sunny. As we drove into Wales, it started raining and we're expecting similar conditions this week.
"We'll adapt to the conditions this week but we still want to go out there and play positive attacking rugby.
"Playing the Six Nations Champions will be a big challenge, but that is why we all love playing Test rugby."
South Africa are expected to name their team to face Wales this Wednesday, with Meyer likely to pick a side packed full of power.
Wales will be looking for a repeat of their 26-19 victory over the Springboks when they christened the Millennium Stadium in style back in 1999 but they will have to buck a historical trend if they are to achieve that feat.
Wales have tasted glory just once in 26 attempts against South Africa and they haven't beaten the Boks since that Millennium Stadium opener.
Wales look to rewrite the history books: South Africa's winning run against Wales
Nov 2000 Wales 13-23 South Africa - Millennium Stadium
Jun 2002 South Africa 34-19 Wales - Bloemfontein
Jun 2002 South Africa 19-8 Wales - Cape Town
Jun 2004 South Africa 53-18 Wales - Pretoria
Nov 2004 Wales 36-38 South Africa - Millennium Stadium
Nov 2005 Wales 16-33 South Africa - Millennium Stadium
Nov 2007 Wales 12-34 South Africa - Millennium Stadium
Jun 2008 South Africa 43-17 Wales - Bloemfontein
Jun 2008 South Africa 37-21 Wales - Pretoria
Nov 2008 Wales 15-20 South Africa - Millennium Stadium
Jun 2010 Wales 31-34 South Africa - Millennium Stadium
Nov 2010 Wales 25-29 South Africa - Millennium Stadium
Sep 2011 South Africa 17-16 Wales - Wellington
Wales' Dove Men Series 2013 fixtures:
Wales v South Africa - Saturday, 9 November, Kick-Off 5.30pm - £70 / £60 / £40 / £25
Wales v Argentina - Saturday, 16 November, Kick-Off 2.30pm - £40 / £30 / £10 concession (U16) /£70 Family ticket 2 adults + 2 concession
Wales v Tonga - Friday, 22 November, Kick-Off 7.30pm - £25 / £10 concession/ £60 Family ticket 2 adult + 2 concession/ Minis/Juniors/Schools offer, with every 8 concessions purchased 2 adult tickets free
Wales v Australia - Saturday, 30 November, Kick-Off 5.00pm - £70 / £60 / £40 / £25