Argentina captain Juan Martin Fernandez Lobbe has been ruled out of the Dove Men Series clash with Wales on November 16.
The 31-year-old flanker fractured his elbow during Toulon's Top14 defeat to Toulouse on Saturday and is set to be sidelined for up to three months.
"Against Toulouse on Saturday flanker Juan Martin Fernandez Lobbe suffered a fracture of the right elbow," read a Toulon statement.
"He will consult a Marseille professor for surgery. It is estimated he will be unavailable for two to three months."
Argentina also face England, Italy and Ireland during their European tour.
Meanwhile former Wales head coach Sir Graham Henry has left his role as technical advisor to Los Pumas.
The World Cup winning-coach has stepped down to focus on a similar role with Super Rugby side the Blues.
He is just the latest departure from the Pumas' coaching staff after Santiago Phelan quit his role in charge. Phelan had been at the helm for six years but will be replaced by Argentina B coach Daniel Hourcade.
The WRU has launched a campaign to create a long term legacy for Welsh club rugby by highlighting the advantages of volunteering. Rhian Edwards, a volunteer at Seven Sisters, has enjoyed many benefits of her volunteering at a grassroots rugby club including being part of the Rugby World Cup volunteer workforce after being nominated by the WRU - and the WRU is asking for more people to develop their 'Welsh rugby roots'.
Wales head coach Warren Gatland and captain Sam Warburton say their first prioirty on Sunday in the opening game of the World Cup is to win against Uruguay and not get overly concerned with points difference.
With only days to go until the biggest rugby competition in the world begins, rugby fans visiting Cardiff this autumn will be able to enjoy a special display at National Museum Cardiff as part of the celebrations surrounding the Rugby World Cup.
Geraint John has taken up the new role of WRU elite coach development manager having arrived in Wales last week. WRU TV caught up with him at the WRU rugby department's strategy day at the Millennium Stadium.
The entire Welsh Rugby Union Rugby Department gathered at the Millennium Stadium earlier this week where WRU Head of Rugby Josh Lewsey looked back on a year where structural and strategic changes have seen significant progress made
The Welsh Rugby Union has released a specially produced video to spearhead a new campaign to help promote the values of rugby union. The video, entitled Let us Play underpins the WRU rugby department's philosophy - to engage, transfer and retain players, coaches and referees.