Argentina captain Juan Martin Fernandez Lobbe has been ruled out of the Dove Men Series clash with Wales on November 16.
The 31-year-old flanker fractured his elbow during Toulon's Top14 defeat to Toulouse on Saturday and is set to be sidelined for up to three months.
"Against Toulouse on Saturday flanker Juan Martin Fernandez Lobbe suffered a fracture of the right elbow," read a Toulon statement.
"He will consult a Marseille professor for surgery. It is estimated he will be unavailable for two to three months."
Argentina also face England, Italy and Ireland during their European tour.
Meanwhile former Wales head coach Sir Graham Henry has left his role as technical advisor to Los Pumas.
The World Cup winning-coach has stepped down to focus on a similar role with Super Rugby side the Blues.
He is just the latest departure from the Pumas' coaching staff after Santiago Phelan quit his role in charge. Phelan had been at the helm for six years but will be replaced by Argentina B coach Daniel Hourcade.
Despite drawing with Ireland in the opening round of the RBS 6 Nations, Wales defence coach Shaun Edwards believes the championship 'is still in our hands' as he prepares his side to face Scotland at Principality Stadium tomorrow.
Meet the members of the WRU's inaugural Youth Board - after an online selection process which saw a host of high calibre candidates submit video applications the WRU has made its first 15 appointments.The board is made up of individuals aged between 16 and 21, and will meet for the first time at Principality Stadium on Monday 15th February.
The Wales Women's team headed to Dare Valley Country Park on a team bonding exercise as the entire squad got together for the very first time in preparation for this season's Six Nations championship which kicks off on Saturday with a clash against defending champions Ireland, in Donnybrook.
Wales Head Coach Warren Gatland discusses his team selection for the opening round of the RBS 6 Nations where he leads his side against Ireland, on Sunday. As WRU TV's Luke Brodley discovers, Gatland is fully aware of the challenges the defending champions pose