Argentina captain Juan Martin Fernandez Lobbe has been ruled out of the Dove Men Series clash with Wales on November 16.
The 31-year-old flanker fractured his elbow during Toulon's Top14 defeat to Toulouse on Saturday and is set to be sidelined for up to three months.
"Against Toulouse on Saturday flanker Juan Martin Fernandez Lobbe suffered a fracture of the right elbow," read a Toulon statement.
"He will consult a Marseille professor for surgery. It is estimated he will be unavailable for two to three months."
Argentina also face England, Italy and Ireland during their European tour.
Meanwhile former Wales head coach Sir Graham Henry has left his role as technical advisor to Los Pumas.
The World Cup winning-coach has stepped down to focus on a similar role with Super Rugby side the Blues.
He is just the latest departure from the Pumas' coaching staff after Santiago Phelan quit his role in charge. Phelan had been at the helm for six years but will be replaced by Argentina B coach Daniel Hourcade.
Wales U20 duo Leon Brown and Lloyd Lewis face a busy couple of weeks ahead. Not only will they have a Junior World Championship to take part in, they are both sitting A Level exams during the competition.
Wales U20 face a tough group in the Junior World Championship with France, England and Japan lying in wait but Attack coach Jason Strange and back rower Tom Phillips are looking forward to the campaign ahead.
Angus O'Brien has quickly settled into the Wales Sevens squad after solid performances in Hong Kong and Japan. With two rounds remaining in Glasgow and Twickenham on the World Series, WRU TV's Graeme Gillespie chats to the rising star.
Wales winger Luke Morgan has established himself as one of the deadliest finishers on the Sevens World Series. WRU TV's Graeme Gillespie catches up with him on the eve of this weekend's round in Glasgow.
All roads lead to Cardiff on Sunday for the SSE SWALEC Finals Day at the Millennium Stadium. Cambrian Welfare tackle Ystradgynlais in the Bowl final, Ystrad Rhondda play Newcastle Emlyn in the Plate final while defending champions Pontypridd face Bridgend in the Cup final.
WRU Chief Executive Roger Lewis, Deputy Minister for Culture, Sport and Tourism Ken Skates and WRU Chairman Gareth Davies earlier this week launched a new competition in conjunction with the WRU unveiling its archive room.
Welsh players and management joined Deputy Minister for Sport Ken Skates at the Pierhead Building, Cardiff Bay earlier this week to reveal the Union's pioneering school-club hub initiative has been so successful the project will now almost double the scale of the original project.
The Scarlets, Newport Gwent Dragons, Cardiff Blues and the Ospreys look ahead to Judgement Day III which sees the Blues take on the Ospreys (2.30) and the Dragons tackle the Scarlets (4.45pm) at the Millennium Stadium tomorrow afternoon.
Ystradgynlais and Ynysddu played out a titanic struggle at Taffs Well in the SSE SWALEC Bowl semi-final. At the end of the game neither team could be separated after a 15-15 stalemate but Ystradgynlais go through on try count.