Charteris has been out of action since December 2012
Luke Charteris could make his long-awaited return to top-class action in Perpignan's Heineken Cup opener with Gloucester on Saturday.
The Wales second-row underwent knee surgery after rupturing ligaments in December 2012.
He was set to make his comeback against Biarritz Olympique in the Top14 on the weekend but made 40-minute cameo appearance for the Catalan club's development side instead.
Charteris suffered no ill-affects from the injury and is now in line to be unleashed upon the Cherry & White's as Europe's premier club competition gets underway.
Perpignan have been drawn in Pool Six, alongside Edinburgh, Gloucester and Munster
Charteris won the first of his 40 Wales caps in 2004 and has been an ever-present feature of their squad in recent years.
But he has not pulled on the Three Feathers since facing Australia just weeks before his injury struck.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.