Charteris has been out of action since December 2012
Luke Charteris could make his long-awaited return to top-class action in Perpignan's Heineken Cup opener with Gloucester on Saturday.
The Wales second-row underwent knee surgery after rupturing ligaments in December 2012.
He was set to make his comeback against Biarritz Olympique in the Top14 on the weekend but made 40-minute cameo appearance for the Catalan club's development side instead.
Charteris suffered no ill-affects from the injury and is now in line to be unleashed upon the Cherry & White's as Europe's premier club competition gets underway.
Perpignan have been drawn in Pool Six, alongside Edinburgh, Gloucester and Munster
Charteris won the first of his 40 Wales caps in 2004 and has been an ever-present feature of their squad in recent years.
But he has not pulled on the Three Feathers since facing Australia just weeks before his injury struck.
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Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series